中药保健烟致慢性阻塞性肺疾病的实验研究  

Experimental study on Chinese health cigarette leading to chronic obstructive pulmonary disease

作　　者：刘佳[1] 赵玉雪[2] 李进涛[2] 倪师今[2] 于浩飞[2] 张荣平[2] 

机构地区：[1]昆明医学院海源学院,昆明650101 [2]昆明医科大学药学院,昆明650500

出　　处：《安徽医科大学学报》2013年第5期463-466,共4页Acta Universitatis Medicinalis Anhui

基　　金：云南省高校药学重点实验室资助项目(编号:2011ZL010)

摘　　要：目的探讨中药保健烟烟气是否会导致SD大鼠慢性阻塞性肺疾病(COPD)。方法 30只SD雄性大鼠随机均分为对照组、中药保健烟组、烟叶组,单纯熏烟下暴露3个月,进行一般体征观察、病理学观察、血常规和支气管肺泡灌洗液(BALF)细胞学检测。结果与对照组比较,中药保健烟组和烟叶组大鼠有明显慢性支气管炎特征性病理学改变,肺组织细胞损伤、管壁炎症细胞浸润、肺泡扩大融合,符合COPD形态学改变;白细胞总数及中性粒细胞明显上升(P<0.01);血清及BALF中的肿瘤坏死因子α(TNF-α)、白介素8(IL-8)含量明显升高(P<0.01)。结论中药保健烟能导致SD大鼠产生COPD病变。Objective Explore whether Chinese health tobaccosmoking gas will result in chronic obstructive pulmonary disease（COPD） in SD rats. Methods 30 male SD rats were randomly divided into control group, Chinese health smoke tobacco group, and cigarette group. SD rats were exposed to fume for three months. The general signs and pathological features were observed, and blood routine tests and BALF cytology were detected. Results Compared with the control group, the Chinese health tobacco group and cigarette group rats showed obvious chronic bronchitis-characteristic pathological changes in lung tissues, such as lung tissue damage, inflammatory cell infiltration and alveolar enlargement and fusion as lung bullae, in line with the morphology of COPD diagnosis ; the number of leukocytes and neutrophils increased obviously （P 〈0. 01 ） ; the IL-8, TNF-α expression in BALF and sera increasd significantly（P 〈 0.01 ）. Conclusion The Chinese health tobacco can lead to COPD.

关 键 词：中药保健烟 慢性阻塞性肺疾病 大鼠 

分 类 号：R563.5[医药卫生—呼吸系统]