冠心病患者介入治疗应用进口和国产药物洗脱支架的成本-效果分析  

Cost-effectiveness analysis of domestic and imported drug-eluting stents implanted in patients with coronary heart disease

作　　者：孙明敏[1] 王连生[2] 赵俊[2] 

机构地区：[1]南京医科大学医政学院,江苏省210029 [2]南京医科大学第一附属医院

出　　处：《江苏医药》2013年第8期944-946,共3页Jiangsu Medical Journal

摘　　要：目的比较冠心病患者介入治疗应用进口和国产药物洗脱支架的成本/效果比。方法选择单纯植入药物洗脱支架的患者270例,根据植入支架的不同分为A[国产雷帕霉素洗脱支架(Partner),86例]、B[进口紫杉醇洗脱支架(Taxus),90例]和C[进口雷帕霉素衍生物佐他莫司洗脱支架(Endeavor),94例]三组。比较三组患者支架内再狭窄率;采用西雅图心绞痛量表对三组患者进行随访,对随访结果进行生存质量分析和成本-效果分析。结果 A、B、C三组支架内再狭窄率分别为3.5%(3/86)、5.6%(5/90)、1.1%(1/94)(P>0.05);A、B组术后心绞痛发作评分高于C组[(94.83±15.36)分、(96.49±9.95)分vs.(86.40±30.64)分(P<0.05)],其余维度无统计学差异;A组成本/效果比明显低于B、C组(P<0.05)。结论国产支架成本/效果比优于进口支架,两者有效性和安全性相似。Objective To compare domestic drug-eluting stents （DES） with imported DES implanted in patients with coronary heart disease by cost-effectiveness analysis; Methods A total of 270 patients implanted with different DES was divided into three groups of A（Partner, 86 cases）, B （Taxus, 90 cases） and C（Endeavor, 94 cases）. The rates of in-segment binary restenosis were compared and Seattle angina questionnaire was used to evaluate life quality and cost-effectiveness ratio in three groups after operation. Results The rates of in-stent binary restenosis were similar in three groups （3. 5%, 5.60% and 1.10%, respectively）（P〉0. 05）. The score of postoperative angina pectoris attaek]n groups of A and B was higher than that in group C[（94. 83±15.36） points and （96.49±9.95） points vs. （86.40±30. 64） points] （P〈0. 05）. The differences of other dimensions in life quality had no statistical significance among three groups. The cost-effectiveness ratio in group A was lower than that in groups of B and C （P〈0. 05）. Conclusion With the similar efficaey and safety, domestic DES shows better cost-effectiveness ratio than imported DES.

关 键 词：冠心病 药物洗脱支架 成本 效果比 

分 类 号：R195[医药卫生—卫生统计学]