甲状腺良恶性结节超声鉴别诊断指标的主成分提取及价值排序  

Extracting principal components from ultrasound indicators in the differential diagnosis of thyroid benign and malignant lesions and ranking valuable indicators

作　　者：马姣姣[1] 徐本华[1] 丁红[1] 毛枫[1] 朱宇莉[1] 纪元[2] 王文平[1] 

机构地区：[1]复旦大学附属中山医院超声科,上海200032 [2]复旦大学附属中山医院病理科,上海200032

出　　处：《中华超声影像学杂志》2013年第4期317-320,共4页Chinese Journal of Ultrasonography

基　　金：卫生公益性行业科研专项经费项目（200802-10）;上海市重点学科建设项目（B112）

摘　　要：目的提取常规超声和超声造影在诊断甲状腺结节中有价值指标的主成分，并分析各指标的诊断价值。方法选择经手术病理证实的103例共125个（良性60个，恶性65个）甲状腺结节的完整超声资料，分析常规灰阶超声、彩色多普勒超声和超声造影显示的18个指标在甲状腺良恶性结节中的分布情况；通过主成分分析法，提取有价值指标的主成分，并获得超声指标的重要性排序。结果灰阶超声和超声造影指标在甲状腺良恶性结节中的分布差异有统计学意义，彩色多普勒超声指标差异无统计学意义。超声造影指标在第1主成分中占据主导地位，各指标的重要性排序为：增强均一度、充盈缺损、结节周边部开始增强时间、结节内部峰值强度、结节内部开始增强时间、结节周边部峰值强度、环状增强。结论常规灰阶超声和超声造影在甲状腺良恶性结节的鉴别诊断中有一定价值。Objective To extract principal components from valuable indicators on conventional ultrasoundand contrast-enhanced ultrasound （CEUS） in the differential diagnosis of thyroid benign and malignant lesions and to discuss the diagnostic value of each indicator. Methods One hundred and three patients with 125 thyroid lesions （65 malignant lesions and 60 benign lesions） underwent preoperative gray- scale ultrasound （GSUS）, color Doppler ultrasound （CDUS） and CEUS examinations. Eighteen indicators were chosen to evaluate every lesion and principal components were extracted by principal component and valuable indicators were ordered by importance. Results There were significant differences on GSUS and CEUS indicators between benign and malignant lesions. The first principal component was the representation of contrast-enhanced ultrasound and was valuable in the differential diagnosis of thyroid benign and malignant lesions. The rank of valuable CEUS indicators were homogeneity of enhancement, filling defect,relative arrival time of periphery, peak interior echogenicity, relative arrival time of interior, peak peripheral echogenicity and ring-enhancement. Conclusions GSUS and CEUS are valuable in the differential diagnosis of thyroid benign and malignant lesions.

关 键 词：超声检查 微气泡 甲状腺疾病 诊断 鉴别 

分 类 号：R445.1[医药卫生—影像医学与核医学]