2009―2011年南京地区碳青霉烯类抗生素应用分析  

Application of carbapenem antibiotics in Nanjing area from 2009—2011

作　　者：房文通[1] 顾凯[2] 罗璨[1] 戴惠珍 陶琳[4] 

机构地区：[1]南京医科大学第一附属医院,江苏南京210029 [2]南京医科大学附属明德医院,江苏南京211166 [3]江苏省医药情报研究所,江苏南京210000 [4]上海市食品药品监督管理局科技情报研究所,上海200233

出　　处：《中国新药与临床杂志》2013年第4期331-334,共4页Chinese Journal of New Drugs and Clinical Remedies

基　　金：江苏高校优势学科建设工程资助项目(JX10231801)

摘　　要：目的评价南京地区2009―2011年碳青霉烯类抗生素的应用情况。方法对南京地区2009―2011年碳青霉烯类抗生素的用药金额和用药频度(DDDs)等进行排序及分析。结果 2009―2011年南京地区碳青霉烯类抗生素用药金额及总DDDs呈增长趋势,年均增长率分别为25.53%和32.39%。居于用药金额及DDDs排名前两位的产品是美罗培南和亚胺培南,金额排序前3的厂商是杭州默沙东制药公司、日本住友制药株式会社和深圳海滨制药厂;国产药的市场份额逐年增加,合资药和进口药的市场份额逐年降低,排名前3名的产品为泰能、美平、倍能。结论 2009―2011年南京地区碳青霉烯类抗生素应用逐年增长,应加强管控以降低细菌对药物的耐药产生速度。AIM To evaluate the clinical utilization of carbapenem antibiotics in Nanjing area from 2009 to 2011. METHODS The consumption sum and frequency of drug use （DDDs） of carbapenem antibiotics in Nanjing area was sorted and analyzed from 2009 to 2011. RESULTS The consumption sum and DDDs of carbapenem antibiotics in Nanjing area both increased from 2009 to 2011, with average annual growth rate 25.53% and 32.39% respectively. The top two carbapenem antibiotics in consumption sum and DDDs were meropenem and imipenem. The top three manufacturers in sales amount were Hangzhou MSD Pharmaceutical Company Limited, Japan Sumitomo Pharmaceuticals Company Limited and Shenzhen Haibin Pharmaceutical Factory. The market share of domestic drugs increased year by year, while the market share of joint drugs and imported drugs reduced year by year. The top three products in sales amount were Tienam, Mepem and Beineng.CONCLUSION The application of carbapenem antibiotics in Nanjing area has increased year by year from 2009 to 2011, and the management of carbapenem antibiotics should be strengthened in order to reduce the generation rate of bacterial drug resistance.

关 键 词：碳青霉烯类 抗菌药 药物利用 经济学 药学 

分 类 号：R956[医药卫生—药学] R978