2型糖尿病肾病患者sGFR及其冠状动脉320-DVCT相关性分析  

Relationship between 99mTc-GFR(sGFR) and Imaging of 320-DVCT in Type 2 Diabetic Patients with Nephropathy

作　　者：舒冏[1] 王曼曼[1] 陈宣容[1] 林可意[1] 江玮[1] 穆攀伟[1] 曾龙驿[1] 

机构地区：[1]中山大学附属第三医院内分泌科,广东广州510630

出　　处：《中山大学学报（医学科学版）》2013年第2期271-275,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省科技计划项目(2010B031600316);广东省自然基金(10151008901000244)

摘　　要：【目的】探讨2型糖尿病肾病患者肾小球滤过率及其冠状动脉粥样硬化程度的相关性。【方法】观察对象是2009年-2012年收集的2型糖尿病肾病住院患者共63例,对患者进行320排动态容积CT(320-DVCT)进行冠状动脉成像检查,并根据320-DVCT结果进行分组,按照冠状动脉的狭窄情况,将患者分为四组:冠状动脉正常组,冠状动脉粥样硬化组,冠状动脉单支病变组,以及冠状动脉多支病变组。使用外源性放射性标记(99mTc-DTPA)测定肾排泄率(sGFR)来评估肾功能,对比各组间sGFR的差异。【结果】各组间比较提示:冠状动脉正常组2型糖尿病肾病患者的sGFR水平均高于冠心病组2型糖尿病肾病患者(P<0.05)。随着冠状动脉分支病变数量的增加,sGFR呈进行性降低(P<0.05)。【结论】2型糖尿病肾病患者sGFR损害程度与冠脉病变严重程度密切相关,sGFR损害越严重,冠脉CTA堵塞情况也越严重。[Objective] To investigate the relationship between the 99mTc-GFR （sGFR） and the imaging of 320-DVCT in type 2 diabetic patients with nephropathy. [Methods] A total of 320 slice dynamic volume CT were done and 99mTc-DTPA GFR were measured in 63 cases of type 2 diabetic patients with nephropathy. According to the coronary stenosis, all cases were divided into four groups： no vessel pathologies group, coronary atherosclerosis group, single vessel group, and muhivessel group. The sGFR between different groups was compared. [ Results ] The levels of sGFR in no vessel pathologies groups were significantly higher than that of in coronary heart disease groups （P 〈 0.05）. As the number of Stenosis of coronary artery increased, the levels of sGFR decreased （P 〈 0.05）. [ Conclusion ] Renal function impairment of sGFR was correlated with the severity of CTA of coronary artery pathologies in type 2 diabetic patients with nephropathy. Meanwhile, the more serious sGFR damage is, the more serious coronary artery disease is.

关 键 词：糖尿病肾病 sGFR 320-DVCT 

分 类 号：R587[医药卫生—内分泌]