卵巢早衰动物模型制备研究进展  

Research progress of the establishment of animal models of premature ovarian failure

作　　者：成杰[1,2] 丁利军[3] 胡娅莉[2] 

机构地区：[1]东南大学医学院,南京210009 [2]南京大学医学院附属鼓楼医院妇产科,南京210008 [3]南京大学医学院附属鼓楼医院生殖医学中心,南京210008

出　　处：《中国比较医学杂志》2013年第4期66-70,共5页Chinese Journal of Comparative Medicine

基　　金：国家973计划项目(2010CB945105)

摘　　要：卵巢早衰是一种典型异质性疾病,病因复杂多样。近年来,卵巢早衰的发病率有明显上升趋势,严重影响妇女身心健康和生活质量。建立一种理想可靠的卵巢早衰动物模型对研究卵巢早衰有着重要的临床意义。本文就国内外学者建立的卵巢早衰动物模型作一综述,讨论比较各种方法的优缺点。Premature ovarian failure （POF） is a typical heterogeneous disease developed due to diverse causes. In recent years, studies show a significant increase of its incidence. POF seriously affect physical and mental health of women. A reproducible and reliable animal model plays an important role in POF research. This review will summarize the relatively successful animal models established by researchers at home and abroad and briefly discuss their advantages and disadvantages.

关 键 词：卵巢早衰 动物模型 雷公藤多苷 

分 类 号：R33[医药卫生—人体生理学]