改善肝脏微循环障碍的必要性和相关中药的筛选  

Resolving blood stasis to improve liver microcirculation and treat chronic liver diseases

作　　者：徐列明[1,2] 

机构地区：[1]上海中医药大学附属曙光医院 [2]上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203

出　　处：《临床肝胆病杂志》2013年第4期257-259,263,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金(No 30672489);上海市教育委员会重点学科(第五期)建设项目(J50307);上海市高校创新团队建设项目(第一期);国家中医药管理局中医肝胆病重点学科(No:2010sh)

摘　　要：慢性肝病常伴有肝脏微循环障碍,使得血液流动减慢甚至流量减少,导致门静脉高压。改善肝脏微循环与干预细胞外基质代谢在抗肝纤维化中具有同等的地位。现代医学的微循环障碍与中医学的瘀血含义有相同之处,应用有抗肝纤维化作用的活血化瘀中药或成分能够改善肝脏微循环、降低门静脉高压。介绍了体内外实验研究中药及组分改善肝脏微循环的作用及机制。Chronic liver diseases are frequently accompanied by changes in the organ＇s microcirculatory system. Changes in the vascular ar- chitecture can affect the rate of blood flow, which in turn may promote the underlying pathogenic etiology ; for example, recent studies have indicated that decreased blood flow in the liver can suppress the clearance rate of pathogenic agents （such as hepatitis virus）, enhance local- ized inflammation and or fibrosis -related injmT, or increase pressure in the portal vein. The phenomenon of obstructed liver microcircula- tion in modern medicine is similar to the pathogenic concept of blood stasis in traditional Chinese medicine （TCM）. Thus, TCM decoctions or methods that promote blood circulation, and have been historically applied to remove blood stasis, may prove useful for treating liver dis- eases. In this review of the promising TCM agents and treatment modalities, we discuss not only the reported outcomes of pharmacological ap- plications in both humans and animal models but also the molecular mechanisms related to the beneficial effects. Future studies should con- tinue to investigate the clinical efficacy of resolving blood stasis to treat portal hypertension, liver fibrosis, and cirrhosis.

关 键 词：慢性肝病 微循环 高血压 门静脉 中草药 活血化瘀剂 

分 类 号：R259[医药卫生—中西医结合]