宣肺止嗽方镇咳化痰作用及其有关机理研究  

Research of Xuanfei Zhisou Prescription for Relieving Cough and Eliminating Phlegm and Related Mechanism

作　　者：李飞侠[1] 朱佳[2] 吴龙传[1] 葛海燕[3] 李娟[3] 

机构地区：[1]南京中医药大学,江苏南京210028 [2]江苏省中医药研究院,江苏南京210028 [3]江苏大学药学院,江苏镇江212013

出　　处：《辽宁中医药大学学报》2013年第5期42-44,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:探讨宣肺止嗽方的镇咳化痰作用及其机理。方法:采用氨水引咳法、酚红排泌法观察宣肺止嗽方对小鼠的镇咳、化痰作用;烟熏法复制慢支模型,观察该方对慢支小鼠肺组织病理形态的影响。结果:宣肺止嗽方可延长小鼠咳嗽潜伏期,高剂量作用显著(P<0.05);抑制小鼠咳嗽次数,高、中剂量效果明显(P<0.01),低剂量无统计学差异,呈现一定的量效关系;明显增加小鼠气管酚红排泌量(P<0.01),亦表现出量效关系;减少慢支模型小鼠肺组织病理形态改变。结论:宣肺止嗽方具有镇咳化痰及减轻慢支模型小鼠肺部炎症改变的作用,提示该方镇咳化痰的作用机理可能与缓解气管炎症有关。Objective：To discuss effect of Xuan^ei Zhisou prescription for relieving cough and eliminating phlegm and its mechanism. Method： Observation of Xuanfei Zhisou prescription on relieving cough and eliminating phlegm of mice was carried on by ammonia water-induced cough method and phenol red excretion method. Replication of chronic bronchitis model was made by fumigation, and lung tissue pathologic morphology in rats was observed. Resuh ： With the increase of dosage of Xuanfei Zhisou prescription, the cough incubation period can be prolonged in mice. High dose was more significant（P〈0.05）. High and middle dose had obvious effect on inhibition of cough （ P〈0.01 ）. The low dose had no statistically significant difference, and showed a certain dose-effect relationship and the phenol red excretion was significantly increased witha certain dose-effect relationship （P〈0.01）. It also can reduce the change of lung tissue pathologic morphology. Conclusion ： Xuanfei Zhisou prescription has the function of relieving cough and eliminating phlegm and reliving airway inflammation. It suggests that the mechanism may be related to the relief of tracheal inflammation.

关 键 词：宣肺止嗽方 镇咳 化痰 支气管炎 

分 类 号：R289.5[医药卫生—方剂学]