无肌松药诱导插入经典喉罩时丙泊酚效应室浓度  

Effect-site concentration of propofol for classic laryngeal mask airway insertion during target-controlled infusion without neuromuscular relaxant

作　　者：黄韶鹏[1] 林雪[1] 李迪[1] 张瑞芹[1] 

机构地区：[1]哈尔滨医科大学附属第二医院麻醉科黑龙江省麻醉与危重病学重点实验室黑龙江省普通高等学校麻醉基础理论与应用研究重点实验室,哈尔滨市150086

出　　处：《临床麻醉学杂志》2013年第4期328-330,共3页Journal of Clinical Anesthesiology

摘　　要：目的测定无肌松药诱导插入经典喉罩丙泊酚靶控输注(TCI)的半数有效浓度(Ce50)。方法择期全麻腹腔镜胆囊切除术患者25例。采用改良序贯法确定丙泊酚效应室靶浓度,初始血浆靶浓度设定为6.0μg/ml,梯度为0.2μg/ml。待丙泊酚血浆靶浓度和效应室浓度平衡时插入喉罩。用概率单位回归法计算丙泊酚Ce50和Ce95及其95%可信区间(CI)。结果丙泊酚Ce50为5.49μg/ml,95%CI为4.99～5.75μg/ml;Ce95为6.07μg/ml,95%CI为5.78～10.75μg/ml。结论无肌松药诱导插入喉罩丙泊酚TCI的Ce50为5.49μg/ml,Ce95为6.07μg/ml。Objective To determine the effect-site concentration of propofol without neuromuscular relaxant for successful classic laryngeal mask airway （CLMA） insertion response in 500% and 95% of patients（Ce50 and Ce95 ）during a target-controlled infusion （TCI）. Methods Twenty- five patients were scheduled for general anesthesia for laparoscopic cholecystectomy. The effect-site concentration of propofol was determined using the modified Dixon＇s up-and-down method. Anesthesia was induced with propofol during a target-controlled infusion at a plasma concentration of 6.0μg/ml （0. 2 μg/ml as a step size）. After equilibrium between the plasma and effect-site concentration of propofol, the CLMA was inserted. Changes of intraoperative hemodynamic were recorded. Probability analysis was used for calculating Ce50, Ce95 and corresponding 95% confidence interval（CI）. Results The Ce50 of propofol was 5.49 μg/ml（95%CI 4.99-5.75 μg/ml）and Ce95 of propofol was 6.07μg/ml（95%CI 5.78-10. 75μg/ml）. Conclusion The Ce50 and Ce95 of propofol for insertion of the CLMA during TCI without neuromuscular relaxant were 5.49μg/ml and 6.07 pg/ml, respectively.

关 键 词：经典喉罩 丙泊酚 靶控输注 

分 类 号：R614[医药卫生—麻醉学]