替加色罗与莫沙必利治疗糖尿病胃轻瘫疗效比较  

Comparison of Tegaserod and Mosapride in the Treatment of Diabetic Gastroparesis

作　　者：王永亮[1] 

机构地区：[1]台州市黄岩区红十字医院内科,浙江台州318020

出　　处：《药物流行病学杂志》2013年第3期117-119,共3页Chinese Journal of Pharmacoepidemiology

基　　金：台州市黄岩区科技局课题(编号:2010059)

摘　　要：目的:比较替加色罗与莫沙必利治疗糖尿病胃轻瘫的疗效。方法:65例糖尿病胃轻瘫患者随机分为治疗组(33例)及对照组(32例)。两组均予控制饮食、适宜运动,同时注射胰岛素或口服抗糖尿病药控制血糖。在此基础上,治疗组加用替加色罗片6 mg,po bid,对照组加用莫沙必利片5 mg,po tid。均为饭前30 min口服。两组疗程均为4周。观察两组4周后临床疗效及治疗后6个月、1年的复发率。结果:治疗4周后,治疗组总有效率为93.94%,明显优于对照组总有效率71.88%(P<0.05)。治疗组6个月和1年的复发率也明显低于对照组(P<0.05)。结论:替加色罗治疗糖尿病胃轻瘫临床疗效较好,明显降低复发率。Objective： To compare the curative effects of tegaserod and mosapride on diabetic gastroparesis. Methods ：65 patients with gastroparesis were randomly divided into treatment group（ 33 cases） and controlled group（ 32 cases）. All the patients got diet-controlling and did suitable exercises. Meanwhile, their blood sugar levels were regulated by injection of insulin or taking oral antidiabetic. Besides, the patients of the treatment group took tegaserod tablets 6mg, po bid, and the patients of the controlled group took mosapride 5mg, po tid. The two drugs were orally taken 30 minutes before meals. The course of the treatment was d weeks. The clinic effects 4 weeks after and recurrence rates within half a year and 1 year were observed. Results：The total effective rate was 93.94% 4 weeks after the treatment, which was significantly higher than that of the controlled group（71.88% , P 〈 0.05 ）. The recurrence rates within 0.5 and 1 year were significantly lower in the treatment group than those of the controlled group（ P 〈 0.05 ）. Conclusion：The treatment of gastroparesis by tegaserod showed a good clinic effect and could reduce the recurrence rate significantly.

关 键 词：替加色罗 莫沙必利 糖尿病胃轻瘫 

分 类 号：R975.7[医药卫生—药品]