克霉唑口腔黏附片的制备及质量评价  

Preparation and Quality Evaluation of Clotrimazole Buccal Adhesive Tablets

作　　者：尹丽芳[1] 王静[1] 张友智[1] 

机构地区：[1]武汉科技大学附属天佑医院,武汉430064

出　　处：《中国药师》2013年第4期540-543,共4页China Pharmacist

摘　　要：目的:制备克霉唑口腔黏附片并评价其质量。方法:采用黏膜粘着剂卡波姆(CP 934)、海藻酸钠、低黏度羧甲基纤维素钠(SCMC),用直接压片法压片制备克霉唑口腔黏附片,并对黏附片的不同参数如药物含量、体外溶胀百分率、药物体外释放度和黏附力进行评价。结果:筛选出最佳配方:克霉唑5 mg,CP 934 30 mg,SCMC 155 mg,聚乙二醇6000 40 mg,乳糖10mg,微晶纤维素8 mg,硬脂酸镁0.5 mg和阿斯巴甜2 mg。结论:成功制备了克霉唑口腔黏附片,其可用于进一步的体内、体外研究。Objective： To prepare and evaluate clotrimazole buccal adhesive tablets. Method： The tablets were prepared by direct compression process using carbopol （ CP 934） , sodium alginate and sodium carboxymethylcellulose low viscosity （ SCMC LV ） as the main adjunvants. The quality of the tablets was evaluated by the parameters of drug content, swelling index, in vitro drug release and mucoadhesive strength. Result： The optimized formula was as follows： clotrimazole of 5 mg, CP 934 of 30 rag, SCMC LV of 155 rag, PEG 6000 of 40 rag, lactose of 10mg, microerystalline cellulose of 8 mg,magnesium stearate of 0.5 mg and aspartame of 2 mg. Con-clusion, The buccal adhesive tablets are Dreoared suceessfullv, and can be used in the further in vivo and in vitro studies.

关 键 词：口腔黏附片 颊吸收 黏膜粘着剂 克霉唑 

分 类 号：R944.4[医药卫生—药剂学]