加味二仙汤联合黄芪鳖甲丸治疗原发性骨质疏松症  

Effect of Modified Erxian Decoctions Combined with Huangqi Biejia Pills on Primary Osteoporosis

作　　者：林俊杰[1] 符名赟[2] 吴声振[1] 

机构地区：[1]佛山市中医院药剂科,广东佛山528000 [2]佛山市中医院骨科,广东佛山528000

出　　处：《中国药师》2013年第4期588-590,共3页China Pharmacist

摘　　要：目的:观察加味二仙汤联合黄芪鳖甲丸治疗原发性骨质疏松症(肝肾不足证)的临床疗效和安全性。方法:93例原发性骨质疏松症(肝肾不足证)患者随机分为治疗组48例和对照组45例。观察组给予加味二仙汤和黄芪鳖甲丸联合治疗,对照组给予骨疏康颗粒治疗,疗程均为6个月。观察两组患者VAS评分、中医临床症状积分和骨密度的变化。结果:两组治疗后VAS评分明显降低(P<0.01);中医临床疗效总有效率治疗组为91.7%,对照组为75.6%,2组总有效率比较,差异有统计学意义(P<0.05);2组骨密度值均有所升高,观察组优于对照组。结论:加味二仙汤联合黄芪鳖甲丸治疗原发性骨质疏松症(肝肾不足证)疗效确切,安全性好,值得临床参考。Objective ： To study the effect and safety of modified Erxian decoctions and Huangqi Biejia pills in the treatment of pri-mary osteoporosis. Method： Totally 93 cases of primary osteoporosis were divided randomly into the control group （45 cases） and the observation group （48 cases）. In the observation group, modified Erxian decoctions combined with Huangqi Biejia pills were used, while in the control group, Gushukang granules were applied. The treatment duration was 6 months. At the end of the study, the VAS score, the integral of clinical symptoms of TCM and bone mineral density were observed. Result： Both the VAS score and bone mineral density were improved in the two groups, while the observation group was better（ P 〈 0.01 ）. The integral of clinical symptoms of TCM showed the total efficient rate for the observation group was 91.7%, and 75.6% for the control group, and the difference between the two groups was statistically significant （P 〈 0.05 ）. Conclusion： Modified Erxian decoctions combined with Huangqi Biejia pills can be applied in the treatment of primary osteoporosis with promising efficacy and safety.

关 键 词：骨质疏松症 肝肾不足证 加味二仙汤 黄芪鳖甲丸 骨密度 

分 类 号：R289.51[医药卫生—方剂学]