深圳市光明新区孕妇及新生儿梅毒感染状况分析  

Study on the status of syphilis infection on pregnant women and neonates in Guangming New District of Shenzhen City

作　　者：李永双 张志云 张晓丽 冉灵芝 林定庄 

机构地区：[1]深圳市光明新区人民医院皮肤科,深圳518106 [2]深圳市光明新区人民医院防保科

出　　处：《现代预防医学》2013年第9期1638-1640,1643,共4页Modern Preventive Medicine

基　　金：深圳市科技计划项目(201003469)

摘　　要：目的了解深圳市光明新区孕妇及新生儿梅毒感染状况,为控制梅毒母婴传播提供参考。方法对首次产检的孕妇建卡并进行免费的甲苯胺红不加热血清试验(TRUST)筛查,试验结果呈阳性者采用梅毒螺旋体明胶颗粒凝集试验(TPPA)进行确认;其分娩的新生儿1个月内用TRUST、TPPA及19S-IgM-梅毒螺旋体明胶颗粒凝结试验(19S-IgM-TPPA)进行检测;对孕妇及新生儿梅毒患者进行规范治疗、电话随访和健康教育。结果 400例孕妇被确诊为妊娠梅毒,患病率为0.66%,其中隐形梅毒及TRUST低滴度者占绝大多数;不同职业、户籍类别、首诊孕周的孕妇梅毒感染率差异有统计学意义;分娩结局中,正常分娩约占一半。400例梅毒孕妇共分娩新生儿212例,其中18例新生儿血清19S-IgM-TPPA检测阳性。结论深圳市光明新区孕妇和新生儿人群梅毒感染率处于较高水平,对妊娠梅毒的早期干预和科学管理是控制梅毒母婴传播的关键。OBJECTIVE To comprehend the status of syphilis infection on pregnant women and neonates in Guangming New District of Shenzhen City and provide references for controlling syphilis maternal-neonatal transmission.METHODS 60 992 pregnant women attending first antenatal care were given a serum screen for syphilis by Toluidine Red Unheated Serum Test（TRUST）and positive cases were confirmed by Treponema Pallidum Particle Agglutination（TPPA）;Their neonates were detected by TRUST,TPPA and 19S-IgM-TPPA.All positive cases were given the standard treatment,health education and regular telephone follow-up.RESULTS 400 cases were diagnosed as pregnant syphilis,and the prevalent rate of pregnant syphilis was 0.66%;the most women were patients of latent syphilis and had low TRUST titre;the prevalent rate of pregnant syphilis varied significantly with the difference of occupation,census register and gestational weeks at first antennal care;in pregnancy outcomes,the cases with normal delivery were half the all.In 212 neonates,18 cases were diagnosed as congenital syphilis by 19S-IgM-TPPA.CONCLUSION The prevalence rate of syphilis in pregnant women and neonates in Guangming New District is at a high level and it is critical to interfere in early and manage effectively pregnant syphilis for controlling syphilis maternal-neonatal transmission.

关 键 词：梅毒 孕妇 新生儿 流行病学 

分 类 号：R759.15[医药卫生—皮肤病学与性病学]