灯盏花素对肝纤维化大鼠肝形态和功能的影响  

Effect of breviscapine on the changes of liver morphology and function in rats with liver fibrosis

作　　者：杨淑艳[1] 钟秀宏[1] 王爽[1] 温娜[1] 赵莹莹[1] 

机构地区：[1]吉林医药学院,吉林132013

出　　处：《现代预防医学》2013年第9期1734-1735,1738,共3页Modern Preventive Medicine

摘　　要：目的探讨灯盏花素对肝纤维化大鼠的保护作用。方法将大鼠随机分为对照组、模型组、水飞蓟宾组和灯盏花素组,采用皮下注射四氯化碳造成大鼠肝纤维化模型,每周两次,连续8周。测定各组大鼠血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)活性、白蛋白(ALB)、总蛋白(TP)、总胆红素(TBIL)含量;观察肝的形态学变化。结果与对照组比较,模型组大鼠血清ALT、AST升高(P﹤0.05或P﹤0.01),ALB降低(P﹤0.01);肝细胞变性坏死明显,纤维组织明显增生;与模型组比较,水飞蓟宾和灯盏花素组血清ALT、AST降低(P﹤0.05),ALB升高(P﹤0.01或P﹤0.05);肝细胞变性、坏死及肝内纤维组织增生明显减轻;与水飞蓟宾组比较,灯盏花素组各项指标均未出现明显差异(P﹥0.05)。结论灯盏花素对肝纤维化大鼠具有保护作用。OBJECTIVE To observe the effect of breviscapine on liver fibrosis in rats.METHODS 40 rats were randomly divided into control group,model group,silybin group,breviscapine group.Hypodermic injection CCI4 was used as liver fibrosis model in mice twice a week for eight weeks.Levels of ALT,AST,ALB,TP,TBIL in serum and liver morphology were tested.RESULTS Compared with control,levels of ALT,AST significantly increased（P﹤0.05 or P﹤0.01）and ALB decreased（P﹤0.01）in model group.Degeneration and necrosis of hepatic cells and fibrous tissue hyperplasia were observed in model group.Compared with model group,levels of ALT,AST significantly decreased（P﹤0.05）and ALB increased（P﹤0.01 or P﹤0.05）in serum,additionally,hepatic injury and fibrous tissue hyperplasia were evidently alleviated in silybin and breviscapine groups.compared with silybin,there was no statistically difference（P﹥0.05）in breviscapine group and silybin group.CONCLUSION Breviscapine has a protective effect on liver fibrosis in rats.

关 键 词：灯盏花素 肝纤维化 形态学 功能 

分 类 号：R285.5[医药卫生—中药学]