Analysis of the Interface between Primary and Secondary Metabolism in Catharanthus roseus Cell Cultures Using ^13C-Stable Isotope Feeding and Coupled Mass Spectrometry  

作　　者：Carla Antonio Natali R. Mustafa Sonia Osorio Takayuki Tohge Patrick Giavalbco Lothar Willmitzer Heiko Rischer Kirsi-Marj Oksman-Caldentey Robert Verpoorte Alisdair R. Fernie 

机构地区：[1]Central Metabolism Group, Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, D-14476 Potsdam-Golm, Germany [2]Natural Products Laboratory, Institute of Biology, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands [3]Present address: Departamento de Biologia Molecular y Bioquimica, Universidad de M.~laga, 29071 M=~laga, Spain [4]Genes and Small Molecules Group, Max Planck Institute of MolecularPlant Physiology, Am Muehlenberg 1, D-14476 Potsdam-Golm, Germany [5]VTT Technical Research Centre of Finland, PO Box 1000, F1-02044 VTT (Espoo), Finland

出　　处：《Molecular Plant》2013年第2期581-584,共4页分子植物（英文版）

摘　　要：Dear Editor, The tropical plant Madagascar periwinkle Catharanthus roseus （L.） G.Don is a rich source of plant-derived medicinal ter-penoid indole alkaloids （TIAs）, including the anti-hypertensive ajmalicine, the sedative compound serpentine, and the anti-cancer drugs vinblastine and vincristine. However, the latter two compounds are produced in C. roseus plants only in very low amounts. Elicitors such as hormones （e.g. jasmonates or salicylic acid） activate plant natural defense responses, includ-ing increased secondary metabolite production （EI-Sayed and Verpoorte, 2007; Lackman et al.. 2011）.Dear Editor, The tropical plant Madagascar periwinkle Catharanthus roseus （L.） G.Don is a rich source of plant-derived medicinal ter-penoid indole alkaloids （TIAs）, including the anti-hypertensive ajmalicine, the sedative compound serpentine, and the anti-cancer drugs vinblastine and vincristine. However, the latter two compounds are produced in C. roseus plants only in very low amounts. Elicitors such as hormones （e.g. jasmonates or salicylic acid） activate plant natural defense responses, includ-ing increased secondary metabolite production （EI-Sayed and Verpoorte, 2007; Lackman et al.. 2011）.

分 类 号：Q946.8[生物学—植物学] Q949.776.5