宫内感染早产儿炎症因子变化的研究  

The research of inflammatory factors in preterm neonates with intrauterine infection

作　　者：李艳红[1] 王凤敏[1] 崔英波[1] 陈钧[1] 覃世榕[1] 

机构地区：[1]宁波市妇女儿童医院新生儿科,浙江宁波315012

出　　处：《中国现代医生》2013年第11期52-53,56,共3页China Modern Doctor

基　　金：浙江省宁波市医学科技计划项目课题(2008014)

摘　　要：目的通过对早产儿血清学相关细胞因子的检测发现其炎症表现,降低早产儿不良结局的发生。方法早产儿生后即取胎盘病检,按胎盘病检分为胎盘炎症组和胎盘无炎症组。分别在出生后1、3天采血,ELISA法监测血IL-6的浓度,并测定C反应蛋白、血培养、白细胞计数。结果胎盘炎症组血IL-6浓度明显高于无炎症组,C反应蛋白、血培养、白细胞计数无差别。结论血IL-6浓度可作为监测早产儿发生炎症反应的早期敏感指标。Objective To investigate the changes of related cytokines in preterm infants with inflammatory response, and reduce adverse outcomes occured in premature infants. Methods After birth the placentas of preterm infants were send to pathological examination. According to placental disease were divided into 2 groups： the placental inflamma- tion group and the placental without inflammation group. At neonates were born after 1, 3 days , we monitored blood concentration of IL-6 by ELISA method, and determined C-reactive protein, blood cultures, white blood cell count. Results The blood concentration of IL-6 in the placental inflammation group were markedly increased; the levels of C-reactive protein, blood cultures and white blood cell count were not changed. Conclusion Plasma IL-6 concentra- tions could be used as a early sensitive index that could discovery inflammatory response in preterm infants.

关 键 词：宫内感染 早产 白细胞介素 炎症反应 

分 类 号：R714.21[医药卫生—妇产科学]