盐酸坦索罗辛治疗输尿管下段结石患者166例临床研究  

Clinical study of tamsulosin on patients with lower ureteral calculi:166 cases

作　　者：赖广平[1] 陈勇[1] 包华宇[1] 梁聪[1] 

机构地区：[1]广西钦州市第二人民医院泌尿外科,535000

出　　处：《临床合理用药杂志》2013年第11期15-16,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察盐酸坦索罗辛治疗输尿管下段结石的临床疗效。方法将322例输尿管下段结石患者随机分为治疗组166例和对照组156例,治疗组予以盐酸坦索罗辛0.4mg口服治疗,对照组予以结石通片2g口服治疗,疗程均为4周。记录并比较2组结石排出率、结石直径、排石时间及药物不良反应情况。结果治疗组结石排出率为90.5%(143/158),高于对照组的30.3%(46/152);结石排出时间为(8±3)d,短于对照组的(14±4)d,差异均有统计学意义(P<0.01)。但2组结石直径和肾绞痛发生率比较差异均无统计学意义(P>0.05)。结论盐酸坦索罗辛能明显促进输尿管下段结石排出,可作为一种有效治疗输尿管下段结石的辅助药物。Objective To observe and assess the clinical effect of tamsulosin in the treatment for lower ureteral calculi.Methods 322 cases of patients with ureterolithiasis in the lower ureter were randomly divided into treatment group (166 cases) and control group (156 cases).The control group was subjected to the regular treatment(Jieshitongpiang 2g Tid for 4 weeks);The treatment group was treated with Tamsulosin(0.4 mg Qd for 4 weeks).The discharge rate of stone,stone diameter,the stone expulsion time and adverse drug reactions of 2 groups were recorded and compared.Results In treatment group,86.1%(143/166)of the patients expelled the calculi and was higher than 29.4%(46/156)in contral group.The mean time of discharged calculis(8±3)d in treatment group was more shorter than the control group(14±4)d,and the differences were statistically significant (P<0.01).There were no significant differences in the incidence of renal colic and stone diameter between 2 groups (P>0.05).Conclusion The tamsulosin could accelerate calculi discharge from lower ureter and increase the discharge rate of calculi,which can be used as an effective auxiliary drug for the treatment of lower ureteral calculi.

关 键 词：盐酸坦索罗辛 结石 输尿管下段 排石 

分 类 号：R693.4[医药卫生—泌尿科学]