药物不良反应682例回顾性分析  

Retrospective analysis of 682 adverse drug reaction reports

作　　者：刘志林[1] 肖丹[1] 彭丽雅[1] 袁进[2] 

机构地区：[1]广东外语外贸大学门诊部,广州市510420 [2]广州军区广州总医院药学部,广州市510010

出　　处：《临床合理用药杂志》2013年第8期27-29,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的分析药物不良反应(ADR)的发生规律及特点,促进临床合理用药。方法对某院2011年12月-2012年5月上报的682例ADR报告进行回顾性分析。结果引起ADR的药物主要为抗菌药物,阿奇霉素、左氧氟沙星、加替沙星高居前3位;给药途径以静脉滴注为主,占90.62%(618/682);78.59%(536/682)在用药30min内发生,45.89%(313/682)持续时间≤1h;临床表现以消化系统、神经系统和感觉器症状最为常见,占80.15%(763/952);40.62%(277/682)可通过调慢滴速使ADR症状好转。结论临床医务人员应重视ADR监测,减少抗菌药物和针剂的过度使用,保障患者用药安全、有效。Objective To analyze the laws and characteristics of adverse drug reaction （ADR） so as to promote rational clinical drug use.Methods 682 cases collected from December 2011 to May 2012 were retrospectively analyzed.Results The drugs that caused ADR were mainly antibiotics,and Azithromycin,Levofloxacin and Gatifloxacin ranked the top three.Intravenous infusion was the main way for drug administration,accounting for 90.62%.78.6% （536/682）of ADR occurred within 30 minutes after using drugs,in which 45.89% is relieved in less than 1 hour.The clinical symptoms are commonly manifested in digestive system,nervous system and sensory organs,occupying 80.15%（763/952）.40.62% of ADR could be relieved by lowering down the speed of intravenous infusion.Conclusion Clinical medical staff should attach great importance to the monitoring of ADRs and control the excessive use of antibacterial and injections with a view to ensuring safe and effective medication.

关 键 词：药物不良反应 监测 抗菌药 注射剂 

分 类 号：R97[医药卫生—药品]