米非司酮和米索前列醇抗早孕出血的治疗  

Treatment of preventing early pregnancy bleedingwith mifepristone and misoprostol

作　　者：王天成[1] 张瑞玲[1] 柴喜荣[1] 

机构地区：[1]漯河市第三人民医院妇产科,河南漯河市462000

出　　处：《井冈山医专学报》2000年第3期17-18,共2页Journal of Jinggangshan Medical College

摘　　要：目的探讨米非司酮和米索前列醇抗早孕出血的有效治疗方法。方法对双米药流胚胎排出当天出血超过月经来潮的第1天出血量者166例进行随机分组治疗 ,A组42例 ,口服乙烯雌酚0 5mg ,1天1次 ,连服6天 ;B组41例行彻底刮宫术 ,其中10例组织送病检 ;C组41例 ,在刮宫同时口服乙烯雌酚0 5mg ,1天1次 ,连服6天 ;D组42例进行对照观察。结果A组出血减少 ,以缩短持续时间为主(P<0 05) ,B组出血减少 ,以减少出血量为主(P<0 05) ,C组在出血量及出血时间上均减少(P<0 01) ,诊刮病理为少量绒毛组织。结论双米抗早孕出血的原因是绒毛残留 ,雌孕激素失衡延长出血时间。彻底诊刮及雌激素替代可减少出血。Objective:Searching for an effective way of treatment of preventing early pregnancy bleeding with mifepristone and misoprostol. Methods: We treated 166 cases whose amount of bleeing of that day after the embryos were carried out with mifepristone and misoprostol was more that of the menses of the first day.42 cases in group A,took diethylstibestrol 0.5mg,qd×6d orally;41 cases in group B were taken dilatation and curettage(D.andC.)completely,among whom to cases tissues were sent to have pathological examination;41 cases in group C,took diethylstibestrol 0.5mg,qd×6d while having D.and C. 42 cases in group D were observed in comparison. Results:Cases in group A had less bleeding,it was mainly to shorten the lasting time(p<0.05).Cases in group B had less bleeding,it was mainly to reduce the amount of bleeding(p<0.05).Cases in group C reduced both the amount of bleeding and the bleeding time(p<0.01),and the pathological tissues were a small amount of villus tissues. Conclusions:The reason of preventing early pregnancy bleeding with mifepristone and misoprostol is the left villus,the unbalanced female pregnant hormone lasts bleeding time.Taking D.and C. Completely and taking the female hormone can rebuce the bleeding.[

关 键 词：米非司酮 米索前列醇 流产 雌激素 刮宫 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]