Dynamics of Micelle Formation from Mixed Lipid Droplets  

组分混合磷脂球胶束化动力学

作　　者：徐蕊[1] 王子璐[1] 李华平[1] 何学浩[2] 

机构地区：[1]天津大学化工学院材料化学与工程专业,天津300072 [2]天津大学理学院化学系,天津300072

出　　处：《Chinese Journal of Chemical Physics》2013年第2期203-210,I0004,共9页化学物理学报（英文）

基　　金：This work was supported by the National Natural Science Foundation of China （No.20974078 and No.91127046）, Computation was carried out in High Performance Computing Center of Tianjin University.

摘　　要：Amphiphilic lipid molecules can form various micelles depending on not only their molecular composition but also their self-assembly pathway. In this work, coarse-grained molecular dynamics simulations have been applied to study the micellization behaviors of mixed dipalmitoylphosphatidylcholine （DPPC）/hexadecylphosphocholine （HPC） droplets. By vary- ing DPPC/HPC composition and the size of lipid droplets, various micelles such as spherical and nonspherical （oblate or prolate） vesicles, disk-like micelles, double or single ring-like and worm-like micelles were observed. It is found that the lipid droplet as an initial state favors forming vesicles and ring-like micelles due to in situ micellization. Our simulation results demonstrate that using special initial conditions combined with various molecular compositions is an effective way to tune lipid micellar structure.

关 键 词：DIPALMITOYLPHOSPHATIDYLCHOLINE Hexadecylphosphocholine Molecular dynam-ics Lipid droplet SELF-ASSEMBLY 

分 类 号：O6[理学—化学]