厄贝沙坦、阿司匹林单独及联合作用对MCAO大鼠模型脑损伤影响的观察  

Observation on the effect of using irbesartan aspirin independently and in combination on MCAO model of rats

作　　者：李春华[1] 王晓东[2] 朱予津[2] 王正[2] 严子平[2] 刘长胜[2] 

机构地区：[1]武警天津总队医院内科,天津300162 [2]武警天津总队医院药械科,天津300162

出　　处：《武警后勤学院学报（医学版）》2013年第4期252-255,共4页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：【目的】利用MCAO模型大鼠研究厄贝沙坦(IRB)、阿司匹林(ASP)在脑卒中后对脑组织的影响。【方法】雄性Wistar大鼠40只随机分为5组:MCAO,IRB+MCAO,ASP+MCAO,IRB+ASP+MCAO,正常对照。连续给药7 d后,I-IV组行MCAO术,24 h后观察行为、梗塞容积、生化指标,SPSS16.0处理实验数据。【结果】预防性给予IRB、ASP的大鼠与单纯MCAO大鼠比较,自发活动率、抓力、过氧化氢酶水平呈上升趋势,梗塞容积、TBARS水平呈下降趋势(P<0.05)。【结论】IRB与ASP有改善脑卒中后脑损伤的作用,联合用药效果更为显著。[Objective] To study the protective effect of irbesartan alone and in combination with aspirin on MCAO model of focal cerebral ischemia in rats. [ Method ] A total of rats were divided into five groups at randome：MCAO, IRB＋MCAO, ASP＋MCAO, IRB＋ ASP＋MCAO and normal control. IRB,ASP and the combination of both were given for 7 days, then focal cerebral ischemia was induced by MCAO for 2h followed by reperfusion for 22h. After 24h of ishemia the rats were studied for behavioral parameters and then sacrificed for infarct volume and estimation of oxidative stress parameters. [Results] Pretreatment by IRB ASP and the combination showed an elevation in locomotor activity; grip strength,catalase and reduction in infract volume,TBARS as compared with MCAO rats （P 〈 0.05）. [ Conclusion ] The protective effects of IRB and ASP is comfired in this study. The combination of both would yield stable beneficial effects.

关 键 词：脑卒中 MCAO大鼠模型 厄贝沙坦 阿司匹林 

分 类 号：R965[医药卫生—药理学]