美托洛尔对慢性心力衰竭患者心率震荡的影响  

Therapeutic effects of metoprolol on heart rate turbulence in patients with congestive heart failure

作　　者：齐帜[1] 张婧[2] 吴蕾[3] 蒋长亮[4] 赵跃萍[5] 

机构地区：[1]解放军第309医院心血管内科,北京100091 [2]空军总医院干部病房,北京100142 [3]武警辽宁总队医院内二科,辽宁沈阳110034 [4]解放军第309医院骨科,北京100091 [5]武警辽宁总队医院内一科,辽宁沈阳110034

出　　处：《武警后勤学院学报（医学版）》2013年第4期283-285,共3页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：【目的】研究美托洛尔干预慢性充血性心力衰竭后心率震荡的变化。【方法】选择有室性早搏的CHF患者60例,分为美托洛尔治疗组31例及对照组29例,所有患者行24 h动态心电图监测计算心率震荡的初始值(TO)、震荡斜率(TS)。【结果】美托洛尔治疗组TO>0,对照组则TO<0;美托洛尔治疗组的TS明显低于对照组。且治疗后HRT明显改善,TO下降,TS升高。【结论】美托洛尔可改善CHF的自主神经功能,进而改善HRT。[ Objective ] To observe the therapeutic effect of metoprolol on heart rate turbulence （HRT） in patients with congestic heart failure （CHF）. [Methods] There 60 patients with premature ventricular beats were divided into metoprolol group consisted of 31 cases and control group consisted of 29 cases . All patients were examined with ambulatory electrocardiogram monitoring for twenty-four hours, and turbulence onset （TO） and turbulence slope （TS） were analyzed, Patients in the metoprolol group were given orally metoprolol. [Results] TO were 〈0 in the control group and〉0 in the metoprolol group. TS was higher in the control group than that of the CHF group. TO decreased and TS increased respectively after oral administration of metoprolol for a month in the metoprolol group. [ Conclusion ] metoprolol can improve function of autonomic nerve in CHF patients in addition to improvement of HRT.

关 键 词：慢性充血性心力衰竭 心率震荡 美托洛尔 

分 类 号：R965[医药卫生—药理学]