鸦胆子油自微乳的制备及溶出度考察  

Preparation and Dissolution Investigation of Brucea javanica Oil Self-microemulsion

作　　者：蒋楠[1] 李晔[2] 陈钢[3] 邵阿丽[3] 孙雯[1] 李彤晖[2] 辛永洁[2] 李丹[1] 

机构地区：[1]陕西中医学院,陕西咸阳712046 [2]陕西省中医药研究院,西安710003 [3]广东药学院,广州510006

出　　处：《中国实验方剂学杂志》2013年第9期45-48,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：陕西省"13115"科技创新工程重大科技专项项目(2009ZDKG-82)

摘　　要：目的:制备鸦胆子油自微乳,并考察其溶出度。方法:通过溶解度试验、气相色谱法筛选辅料,伪三元相图优化自微乳处方,并进行药物溶出度试验。结果:鸦胆子油自微乳最优处方为鸦胆子油-辛酸癸酸三甘油酯-聚氧乙烯氢化蓖麻油-聚乙二醇400 12∶12∶65∶11,乳滴粒径<50 nm,15～20 min可基本完全溶出。结论:鸦胆子油自微乳稳定性良好,提高了用药的顺应性,且制备工艺简单。Objective：To prepare Brucea javanica oil self-microemulsion,and investigate its dissolution.Method： Solubility test and gas chromatography were used to select adjuvants,pseudo-ternary phase diagram was used to optmize prescription of the self-microemulsion,and dissolution test of the self-microemulsion was adopted.Result： Optimum prescription of B.javanica oil self-microemulsion was B.javanica oil-caprylic capric triglyceride-polyoxyethylene hydrogenated castor oil-polyethylene glycol 400 12%∶ 12%∶ 65%∶ 11%,particle size of it was＆lt;50 nm and it could be completely dissolved in 15-20 minutes.Conclusion： B.javanica oil self-microemulsion had good stability,it improved medication compliance,and this preparation technology was simple and stable.

关 键 词：鸦胆子油 自微乳化系统 伪三元相图 溶出度 

分 类 号：R283.6[医药卫生—中药学]