阿司匹林对多囊卵巢综合征患者妊娠不良因素的改善作用  

THE EFFECT OF ASPIRIN ACTION ON BAD FACTOR THAT INFLUENCE PREGNANCY RATE OF PCOS

作　　者：刘萍[1] 何艳舫[1] 刘洋[2] 韩素新[1] 

机构地区：[1]河北联合大学附属医院妇产科,河北省唐山市063000 [2]河北联合大学冀唐学院护理系

出　　处：《中国煤炭工业医学杂志》2013年第4期528-530,共3页Chinese Journal of Coal Industry Medicine

基　　金：河北省唐山市科学技术研究与发展计划项目;课题号12140209A-54

摘　　要：目的探讨小剂量阿司匹林对影响多囊卵巢综合征患者妊娠结局部分不良因素的作用。方法选择2012年1—5月来我院门诊就诊的多囊卵巢综合征(PCOS)患者为研究对象,所有研究对象均纠正异常激素水平后随机分为二组,观察组首先给予口服小剂量阿司匹林50mg/d,连续3个月后行促排卵指导受孕。对照组未用药物治疗直接促排卵治疗并指导受孕,对二组的妊娠率及其影响因素进行分析。结果观察组的临床妊娠率为29.2%,对照组的临床妊娠率为17%,二组患者的妊娠率比较差异有统计学意义(P<0.05)。Logistic分析显示,肥胖、胰岛素抵抗、高血脂、内膜评分异常是非用药组导致妊娠失败的危险因素。肥胖、高血脂是观察组导致非妊娠的危险因素。结论 PCOS患者规范的给予小剂量阿司匹林,可以改善影响PCOS患者妊娠的不良因素,从而提高妊娠率。Objective To analyze the effect of low dose aspirin action on risk factor that influence pregnancy rate of PCOS.Methods Total 82 PCOS patients were selected between Jan.2012 and May.2012 in auhtor's hospital.All subjects were randomly divided into two groups after redressing hormone level,the medication group took low dose aspirin(50mg/d) orally for three months,the control group was no medication.The pregnancy rate and its correlation factors were analyzed.Results The pregnant rate was 29.2% and 17.0% in medication group respectively,and the defference was statistically significant(P<0.05).The logistic results showed that fat,IR,hyperlipoidemia,abnormal of endometrium score were risk factors for nonpregnant group,and fat,hyperlipoidemia for control group.Conclusion For PCOS patients,low dose aspirin orally can promote the bad factor and improve the pregnancy rate.

关 键 词：多囊卵巢综合征 阿司匹林 不良因素 

分 类 号：R971.2[医药卫生—药品]