软坚消瘿颗粒中挥发油提取及β-环糊精包合工艺研究  

Study on Process of Volatile Oils Extraction and β-Cyclodextrin Clathrates of Ruanjian Xiaoying Granules

作　　者：张兰[1] 韩毅[1] 樊程程[2] 杨彬婕[2] 刘阳[2] 董津含[2] 

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032 [2]辽宁中医药大学,辽宁沈阳110032

出　　处：《中华中医药学刊》2013年第5期974-975,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：沈阳市科技局资助项目(F10-149-9-11)

摘　　要：目的:优选软坚消瘿颗粒的挥发油提取及β-CD包合物工艺。方法:以挥发油得率,挥发油包合率为指标,采用L9(34)正交实验设计,优选挥发油提取及β-CD包合物工艺。结果:最佳提取工艺为用6倍量水浸泡药材2 h,水蒸气蒸馏法提取6 h。最佳包合工艺为β-CD:软坚消瘿颗粒挥发油=10:1(g.mL-1),包合温度为40℃,包合时间为1.5 h;A2B3C3为优选出的最佳工艺方案。结论:本工艺包合物含量较高,工艺稳定且操作简便,可用于软坚消瘿颗粒的生产中。Objective：To optimize the volatile oils extraction and β-cyclodextrin clathrates process of Ruanjian Xiaoying Granules.Methods：The orthogonal test of L9（34）was used to optimize the volatile oils extraction and β-cyclodextrin clathrates process of Ruanjian Xiaoying Granules with the content of the volatile oils of yeild and considered close rate as indexes.Results：The best extracting process was using 6 times water to immersion for 2 hours then extracting for 6 hours.The best preparation process was as follows：β-cyclodextrin：compound Ruanjian Xiaoying Granules=10：1（g·mL-1）,at 40℃ for 1.5 hours.A2B3C3 was the best extraction scheme.Conclusion：The preparation process can be a scheme to obtain the clathrate with high content of effective component,which can be used in the preparation of the clathrate.

关 键 词：软坚消瘿颗粒 正交设计 挥发油提取工艺 β-CD包合工艺 

分 类 号：R284.2[医药卫生—中药学]