参竹心康汤对慢性心衰患者血管内皮功能影响的临床研究  

Clinical Study on Effect of Shenzhu Xinkang Decoction on Vascular Endothelium Function of Patients with Chronic Heart Failure

作　　者：喻正科[1] 朱筱婧[1] 陈志红[1] 朱棱[1] 谭宇军[1] 

机构地区：[1]湖南省中医药研究院附属医院,湖南长沙410006

出　　处：《中华中医药学刊》2013年第5期1019-1021,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：湖南省卫生厅中医药科研基金资助项目(2009041)

摘　　要：目的:观察参竹心康汤对慢性心衰患者心功能与血管内皮功能的影响。方法:将91例慢性心衰患者随机分为治疗组46例,对照组45例。对照组以西医常规治疗,治疗组在此基础上加服参竹心康汤。以内皮素(ET)、降钙素基因相关肽(CGRP)、每分输出量(CO)、左室短轴缩短率(FS)、左室射血分数(LVEF)、舒张早期流速峰值(EPFV)/舒张晚期流速峰值(APFV)即E/A作为观察指标。结果:两组间心衰疗效差异有统计学意义(P<0.05);两组中医证候疗效差异有显著统计学意义﹙P<0.01);反映血管内皮功能指标ET、CGRP两组治疗前后差异有统计学意义﹙P<0.05～0.01),组间疗效比较治疗组优于对照组(P<0.01);反映左室收缩功能的指标CO、FS、LVEF两组治疗前后差异有统计学意义(P<0.05～0.01),组间疗效比较治疗组优于对照组(P<0.05～0.01);反映左室舒张功能的指标E/A两组治疗前后差异有显著统计学意义(P<0.01),组间疗效比较治疗组优于对照组(P<0.01)。结论:参竹心康汤可提高慢性心衰患者的临床疗效,改善血管内皮功能及收缩与舒张功能。Objective：To observe the effect of Shenzhu Xinkang Decoction on heart function and vascular endothelium function of patients with chronic heart failure.Methods：Ninety-one patients with chronic heart failure were enrolled and randomly divided into the treatment group（n=46）and the control group（n=45）.Both groups of were managed with conventional western medicine therapy,only the patients of treatment group were administered by Shenzhu Xinkang Decoction.The indexes of the patients were observed as follows：endothelin（ET）,calcitonin gene related peptide（CGRP）,minute volume（CO）,left ventricular fractional shortening（FS）,left ventricular ejection fraction（LVEF）,peak early diastolic velocity（EPFV）/late diastolic peak flow rate（APFV）or（E/A）.Results：The differences in effect of heart failure between the two groups were statistically significant﹙P0.05）.The improvement in TCM syndrome between the two groups was significantly different﹙P0.01）.The indexs of ET and CGRP used for evaluating vascular endothelium function in both groups before and after treatment were statisticallydifferent﹙P0.05,P0.01）,the indexes in treatment group were superior to that in control group（P0.01）.The indexs of CO,FS and LVEF used for evaluating left ventricle systolic function in both groups before and after treatment were statistically significant（P0.05,P0.01）,the indexes in treatment group were superior to that in control group（P0.05~0.01）.The index of E/A used for evaluating right ventricle diastolic function in both groups before and after treatment were statistically significant（P0.01）,the index in treatment group was superior to that in control group（P0.01）.Conclusion：Shenzhu Xinkang Decoction may be useful for the clinical treatment of chronic heart failure and can improve vascular endothelial function and systolic and diastolic function.

关 键 词：参竹心康汤 慢性心衰 血管内皮功能 收缩与舒张功能 

分 类 号：R259.416[医药卫生—中西医结合]