针刺留针与否对早期脑缺血再灌注大鼠血清TNF-α表达的影响  

Effect of Retaining Acupuncture or Not on the Expression of TNF-α in Early Cerebral Ischemia and Reperfusion Rats

作　　者：张天生[1] 杨晶[2] 韩润霞[2] 张世渊[3] 

机构地区：[1]山西省针灸研究所,山西太原030006 [2]山西中医学院,山西太原030024 [3]山西省人民医院,山西太原030012

出　　处：《中华中医药学刊》2013年第5期1093-1094,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：山西省青年基金资助项目(20100210383)

摘　　要：目的:研究针刺留针与否对早期脑缺血再灌注大鼠脑损伤的保护作用。方法:40只SD大鼠,随机分为正常对照组、假手术组、大脑中动脉阻塞(MCAO)模型组、MCAO留针组及MCAO不留针组。MCAO留针组在造模后2 h、24 h固定针刺三阴交、内关、人中,留针30 min,MCAO不留针组针刺时间、穴位均同MCAO留针组,针刺后不留针。造模48 h后,测定各组大鼠血清中TNF-α的含量。结果:(1)MCAO留针组和MCAO不留针组TNF-α含量低于MCAO模型组,统计学比较P<0.05;(2)MCAO留针组与不留针组血清中TNF-α水平比较无明显差异(P>0.05)。结论:脑缺血再灌注早期,针刺后留针与否均可降低大鼠血清中TNF-α的水平且并无明显差异。Objective：To study different protective effects of retaining acupuncture or not on early cerebral ischemia and reperfusion rats.Methods：Forty male SD rats were randomly divided into normal control group,sham group,the middle cerebral artery occlusion（MCAO）model group,MCAO needling retention and MCAO needling unretention group.MCAO needling retention group needled SP6（Sanyinjiao）,PC6（Neiguan）and DU26（Renzhong）,keeping the needle in the body for 30 minutes in the two hours and twenty-four hours after the model.MCAO needling unretention group needled the same position and the time without leaving the needle in rats＇ body.The content of TNF-α in serum was measured forty-eight hours later.Results：（1）The content of TNF-α in serum of MCAO needling retention and MCAO needling unretention group was lower than that in the MCAO model group,there was statistical significance between them（P0.05）.（2）There was no statistical significance on the content of TNF-α in serum levels between MCAO needling retention and needling unretention group（P0.05）.Conclusion：Acupuncture needle retention or not can reduce the level of TNF-α.There may be no difference in the reduce degree.

关 键 词：脑缺血再灌注 针刺 留针 TNF-Α 

分 类 号：R245.31[医药卫生—针灸推拿学]