聚乙二醇干扰素联合利巴韦林对慢性丙型肝炎患者中医辨证分型的影响  

Effect of pegylated interferon combined with ribavirin on TCM syndrome differentiation in patients with chronic hepatitis C

作　　者：许文君[1] 李秀惠[1] 李红艳[1] 勾春燕[1] 靳华[1] 李晶滢[1] 邱金鹏[1] 汪晓军[1] 

机构地区：[1]首都医科大学附属北京佑安医院,北京100069

出　　处：《北京中医药》2013年第4期269-271,共3页Beijing Journal of Traditional Chinese Medicine

基　　金：国家科技重大专项(2008ZX10005-009;2012ZX10005010-002);北京市科技新星资助项目(2008-A088)

摘　　要：目的观察聚乙二醇干扰素联合利巴韦林治疗对慢性丙型肝炎患者中医辨证分型的影响。方法采用前瞻性研究方法,对28例慢性丙型肝炎患者应用聚乙二醇干扰素联合利巴韦林治疗,收集患者治疗前后的中医证候资料,并进行统计学分析。结果 28例患者治疗前后中医症状积分变化差异有统计学意义(P<0.01),面色晦暗和面色无华较治疗前明显减轻。治疗前慢性丙型肝炎的中医证型分布规律为正虚邪恋证>肝郁脾虚证=肝肾阴虚证>湿热中阻证=脾肾阳虚证>瘀血阻络证;治疗后为肝郁脾虚证>正虚邪恋证>脾肾阳虚证>湿热中阻证=肝肾阴虚证;治疗后肝郁脾虚证患者比治疗前明显增多,差异有统计学意义(P<0.01)。结论聚乙二醇干扰素联合利巴韦林抗病毒治疗可对中医证型分布规律产生影响,主要表现为肝郁脾虚证增多。Objective To observe the effect of pegylated interferon combined with ribavirin on TCM syndrome differentiation in patients with chronic hepatitis C. Methods A prospective study was conducted of twenty-eight cases with chronic hepatitis C who received a treatment of pegylated interferon combined with ribavirin, the patients＇ information of TCM syndrome before and after the treatment were collected and analyzed in statistics. Results The change of TCM symptom score in 28 eases before and after the treatment had significant difference （P 〈 0.01）. The symptoms of dim complexion and lusterless complexion were relieved obviously compared before the treatment. The distribution law of TCM syndrome in chronic hepatitis C before the treatment was syndrome of healthy-qi deficiency and pathogen-factor lingering 〉 syndrome of liver-depression and spleen-deficiency = fin-deficiency of liver-kidney syndrome 〉 syndrome of dampness-heat obstructing the middle energizer = yang-defieiency of spleen-kidney syndrome 〉 syndrome of stasis-blood obstructing the collaterals; while after the treatment syndrome of liver-depression and spleen-deficiency 〉 syndrome of healthy-qi deficiency and pathogen-factor lingering 〉 yang-deficieney of spleen-kidney syndrome 〉 syndrome of dampness-heat obstructing the middle energizer = yin-defieieney of liver-kidney syndrome; the syndrome of liver-depression and spleen-deficiency was obviously increased after the treatment with significant difference （P 〈 0.01）. Conclusion The anfiviral treatment of pegylated interferon combined with ribavirin has an effect on distribution law of TCM syndrome, manifesting the increase of the liver-depression and spleen-deficiency syndrome.

关 键 词：慢性丙型肝炎 聚乙二醇干扰素 利巴韦林 中医辨证分型 

分 类 号：R259[医药卫生—中西医结合]