手参对高脂血症大鼠血脂及肝功能的影响  

Effect of the extract of Gymnadenia conopsea on the blood lipid and liver function in experimental hyperlipidemia rats

作　　者：张天娥[1] 陈朝勇[2] 李少华[2] 陈冲[2] 刘伟伟[1] 闫智勇[2] 

机构地区：[1]成都中医药大学基础医学院,四川成都611137 [2]西南交通大学生命科学与工程学院,四川成都610031

出　　处：《时珍国医国药》2013年第4期865-867,共3页Lishizhen Medicine and Materia Medica Research

基　　金：教育部中央高校基本科研业务费专项资金(No.SWJTU09CX063)

摘　　要：目的探讨手参对高脂血症大鼠血脂及肝功能的影响。方法采用高脂饲料建立大鼠高脂血症模型,观察手参醇提物对模型大鼠血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)及肝组织TC、TG的影响。结果和空白对照组相比,模型组大鼠血清TC、TG、LDL-C、ALT、AST及肝组织中TC、TG含量均显著升高(P<0.05,P<0.01)。而高、中、低剂量手参乙醇提取物均能不同程度地降低血清TG、ALT、AST及肝组织TG的含量(P<0.05,P<0.01)。结论手参对实验性高脂血症大鼠具有一定降脂作用,并能保护脂质代谢紊乱造成的肝损伤。Objective To observe the effect of the extract of Gymnadenia conopsea on the blood lipid and liver function in experimental hyperlipidemia rats. Methods The high-fat diets were used to make the hyperlipidemia model of rat.The rats were treated by the extract of Gymnadenia conopsea.The serum TC,TG,LDL-C,HDL-C,ALT,AST and liver TC,TG were detected after the last administration. Results Compared with blank control group,the content of serum TC,TG,LDL-C,ALT,AST and liver TC,TG increased significantly(P<0.05,P<0.01) in the model group.However the extract of Gymnadenia conopsea may have effect on decreasing the content of serum TG,ALT,AST and liver TG(P<0.05,P<0.01). Conclusion Gymnadenia conopsea could reduce the blood lipid and protect the liver function in experimental hyperlipidemia rats.

关 键 词：手参 高脂血症大鼠 血脂 肝功能 

分 类 号：R285.5[医药卫生—中药学]