普通干扰素α-2b与聚乙二醇干扰素α-2a在慢性丙型肝炎抗病毒治疗中快速及早期病毒学应答的临床分析  

Clinical analysis of pegylated interferon oL-2a and ordinary interferon a-2b in antiviral treatment of chronic hepatitis C

作　　者：张英英[1] 武淑环[1] 安敬军[1] 李志勤[1] 张红宇[1] 殷辉[1] 

机构地区：[1]郑州大学第一附属医院感染科,450052

出　　处：《中国实用医刊》2013年第10期48-50,共3页Chinese Journal of Practical Medicine

摘　　要：目的研究干扰素类型及丙肝病毒载量对慢性丙型肝炎抗病毒治疗应答的影响。方法选择297例慢性丙型肝炎患者为研究对象，对抗病毒治疗的应答情况与干扰素类型及丙肝病毒载量的关系进行回顾性分析。结果在HCVRNA≥105IU／ml组，聚乙二醇干扰素（a-2a抗病毒治疗获得快速病毒学应答（RVR）率为74．7％，早期病毒学应答率（EVR）为81．6％，普通干扰素a-2b组RVR获得率为58．7％，EVR获得率为62．5％，组间比较差异有统计学意义（P〈0．05）。而在HCVRNA〈105IU／ml组，聚乙二醇干扰素a-2a组获RVR率为80．9％，EVR率为88．2％，普通干扰素a-2b组获RVR率为80．6％，EVR率为85．5％，组问比较差异无统计学意义（P〉0．05）。结论在病毒载量较高的情况下，聚乙二醇干扰素（a-2a针较普通干扰素a-2b针抗病毒治疗的RVR及EVR获得率高。而在病毒载量较低的情况下，聚乙二醇干扰素（a-2a针与普通干扰素a-2b针抗病毒治疗的RVR及EVR获得率差异无统计学意义。Objective To investigate the effect of interferon types and hepatitis C viral load on anti-viral treatment response of chronic hepatitis C. Methods The clinical data of 297 chronic hepatitis C who received antiviral treatment was studied, the correlation of response condition with interferon types and hepatitis C viral load was retrospectively analyzed. Results In HCV RNA above 105 IU/ml case, pegylated interferon a-2a received RVR was 74.7% , EVR was 81.6% , ordinary interferon a-2b re- ceived RVR was 58.7%, EVR was 62.5%. In HCV RNA below 105 IU/ml case, pegylated interferon a-2a received RVR was 80.9%, EVR was 88.2%, ordinary interferon a-2b received RVR was 80. 6%, EVR was 85.5%. Conclusions When HCV RNA load was higher, pegylated interferon a-2a received higher rapid virological rate and early virological response than ordinary interferon a-2b. When HCV RNA load was lower, interferon type response to antiviral therapy was not statistically significant.

关 键 词：慢性丙型肝炎 聚乙二醇干扰素A-2A 普通干扰素a-2b 快速病毒学应答 早期病毒学应答 

分 类 号：R512.63[医药卫生—内科学]