肥胖相关基因PID1的研究进展  

Review on Obesity Relevant of PID1 Gene

作　　者：徐洪刚[1] 郑程莉[1] 徐刚毅[1] 

机构地区：[1]四川农业大学动物科技学院,四川雅安625014

出　　处：《中国畜牧杂志》2013年第9期92-96,共5页Chinese Journal of Animal Science

基　　金：国家现代肉羊产业技术体系"十二五"项目(CARS-39)

摘　　要：人和动物脂肪代谢受到多种因素的调节,其中最重要的是遗传因素。磷酸酪氨酸互作结构域1(PID1)是近年来发现的新基因,作为一种信号分子在细胞生长和成脂过程中直接作用,在脂肪组织中都出现PID1的高表达现象,这就提示了PID1基因和脂肪沉积存在关系。本文将系统介绍PID1基因结构、编码产物特征以及其对肥胖影响作用机理及其研究进展。Human and animal fat metabolism is regulated by a varies of factors and the most important factor is the genetic factor. Phosphotyrosine interaction domain 1 （PID1） is a new gene discovered in recent years, which has a direct role in the cell growth and lipid process as a signaling molecule, overexpresses in the fat ceils directly leaded to produce obesity phenotype. This article will be introduced the PID1 gene structure, coding, product characteristics and its regulatory role in cell growth and adipogenic process.

关 键 词：结构 肥胖 脂肪 PID1基因 

分 类 号：S852.2[农业科学—基础兽医学]