正交试验优选复方芩苍鼻喷雾剂中黄芩和苍耳子的提取工艺  

Optimization of Extraction Technology of Scutellaria baicalenisis and Xanthium sibiricum from Compound Qincang Nasal Spray by Orthogonal Test

作　　者：韩宪忠[1] 金蜀蓉[1] 柯昌毅[1] 车坷科[1] 谢剑锋[1] 

机构地区：[1]重庆市第三人民医院药剂科,重庆400014

出　　处：《中国药房》2013年第19期1768-1770,共3页China Pharmacy

摘　　要：目的:优选复方芩苍鼻喷雾剂中黄芩和苍耳子的提取工艺。方法:以黄芩苷质量分数和浸膏收率的综合评分为评价指标,以乙醇浓度、乙醇用量、回流次数、回流时间为考察因素,采用正交试验优选工艺。结果:优选的工艺为药材加12倍量70%的乙醇,提取2次,每次1h。结论:该工艺稳定、可行,可用于复方芩苍鼻喷雾剂中黄芩和苍耳子的提取。OBJECTIVE： To optimize the extraction technology of Scutellaria baicalenisi and Xanthium sibiricum from Com- pound qincang nasal spray. METHODS： The extraction technology was optimized by orthogonal design with concentration and amount of alcohol, refluxing time and refluxing times as factors using the mass fraction of baicalin and the yield of solid extracts as index. RESULTS： The best extraction technology was 12-fold 70% alcohol, extracting for 2 times and lasting for 1 h each time. CONCLUSIONS： The optimum process is stable and feasible for the extraction of Scutellaria baicalensis and Xanthium sibiricum from Comnound oincang nasal sorav.

关 键 词：黄芩苷 提取工艺 正交试验 复方芩苍鼻喷雾剂 

分 类 号：R283.61[医药卫生—中药学] R284.2[医药卫生—中医学]