正交试验优选黄芩苷二元醇质体制备工艺  

Optimization of the Preparation Technology of Baicalin Binary Ethosomes by Orthogonal Design

作　　者：金思岑[1] 

机构地区：[1]太极集团有限公司,重庆401147

出　　处：《中国药房》2013年第19期1777-1779,共3页China Pharmacy

摘　　要：目的:优选黄芩苷二元醇质体的制备工艺。方法:以黄芩苷与卵磷脂质量比、含醇质量分数、无水乙醇与丙二醇体积比为考察因素,以包封率为评价指标,采用注入法制备黄芩苷二元醇质体,通过正交试验优选制备工艺。结果:优选的制备工艺为黄芩苷与卵磷脂质量比1∶20,含醇质量分数10%,无水乙醇与丙二醇体积比6∶4,在此条件下,黄芩苷二元醇质体的包封率为76.51%。结论:所选工艺合理、可行,可用于黄芩苷二元醇质体的制备。OBJECTIVE： To optimize the preparation technology of Baicalin binary ethosomes. METHODS： Baicalin binary ethosomes were prepared by ethanol injection method. The preparation technology was optimized by orthogonal design with ratio of baicalin to lecithin, mass fraction of ethanol, volume ratio of absolute ethanol to propanediol as factors using encapsulation efficien- cy as index. RESULTS ： Optimal preparation technology was as follows ： ratio of baicalin to lecithin was 1 ： 20; mass fraction of eth- anol was 10% ; volume ratio of absolute ethanol to propanediol was 6 ： 4. The encapsulation efficiency of the preparation was 76.51% under this condition. CONCLUSIONS： The optimized formulation is reasonable and feasible, and it can be used for the preparation of Baicalin binary ethosomes.

关 键 词：黄芩苷 二元醇质体 制备工艺 

分 类 号：R283[医药卫生—中药学] R284.2[医药卫生—中医学]