大黄、丹参对重症急性胰腺炎患者的临床疗效观察  

Therapeutic Efficacy of Rheum palmatum and Salvia miltiorrhiza on Patients with Severe Acute Pancreatitis

作　　者：牛威[1] 郭莲怡[1] 

机构地区：[1]辽宁医学院附属第一医院消化科,辽宁锦州121001

出　　处：《中国药房》2013年第19期1801-1803,共3页China Pharmacy

摘　　要：目的:观察大黄、丹参对重症急性胰腺炎(SAP)患者的临床疗效。方法:将46例SAP患者随机分为对照组和治疗组,对照组仅采用常规治疗;治疗组在常规治疗基础上加用大黄水提物与丹参注射液。检测治疗前与治疗后8d两组患者血清肿瘤坏死因子(TNF)-α、血管内皮生长因子(VEGF)水平,并评价两组患者临床疗效;观察血淀粉酶水平、白细胞水平恢复正常时间;腹痛缓解时间与平均住院时间。结果:与对照组比较,治疗后治疗组患者血清中TNF-α、VEGF含量显著下降(P<0.05),临床总有效率显著升高(P<0.05),血淀粉酶水平、白细胞水平恢复正常时间、腹痛缓解时间与平均住院时间显著缩短(P<0.05)。结论:大黄、丹参能抑制TNF-α分泌,下调VEGF水平,对SAP具有良好的治疗作用。OBJECTIVE： To observe the therapeutic efficacy of Rheum palmatum and Salvia miltiorrhiza on patients with severe acute pancreatitis （SAP）. METHODS： 46 patients with SAP were randomly divided into treatment group and control group. Control group only received conventional therapy of western medicine, and treatment group was additionally given R. palmatum and Danshen injection on the basis of conventional treatment. Serum levels of TNF-α and VEGF were determined before treatment and after 8 d treatment, and therapeutic efficacies were evaluated in 2 groups; recovery time of serum amylase and white blood cell were observed; pain relief time and the average length of stay were also recorded. RESULTS： Compared with control group, serum content of TNF-α and VEGF in blood serum were decreased significantly（P〈0.05）, while overall response rate was increased significantly; recovery time of serum amylase and white blood cell pain relief time and the average length of stay time were significantly shortened （P〈0.05）. CONCLUSIONS： R. palmatum and S. miltiorrhiza can inhibit TNF-α secretion, reduce VEGF levels, and has a good therapeutic effect on SAP.

关 键 词：重症急性胰腺炎 肿瘤坏死因子Α 血管内皮细胞生长因子 大黄 丹参注射液 

分 类 号：R657.5[医药卫生—外科学] R97[医药卫生—临床医学]