胎盘蛋白14在子宫内膜异位症发病中的作用  

The primary study on role of placental protein 14 in pathogenesis of endometriosis

作　　者：王萍[1] 朱丽波[2] 苏琴芬[1] 张信美[2] 

机构地区：[1]上海市闸北区中心医院妇科,上海200070 [2]浙江大学医学院附属妇产科医院,浙江杭州310006

出　　处：《中国实用妇科与产科杂志》2013年第5期364-367,共4页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：国家自然基金(81270672);浙江省自然基金(Y2110181;Y2110128);上海市浦江人才计划基金(10PJ1409000)

摘　　要：目的探讨子宫内膜异位症(内异症)患者血清和腹腔液中胎盘蛋白14(PP14)在内异症发病中的作用。方法 2010年1月至2012年10月在浙江大学医学院附属妇产科医院应用酶联免疫法分别检测75例卵巢子宫内膜异位囊肿患者及49例对照组血清与腹腔液PP14和CA125水平,同时应用免疫组织化学方法检测卵巢子宫内膜异位病灶组织中PP14的表达水平。结果内异症患者的血清PP14和CA125水平均显著高于对照组(P均<0.05);GnRHa治疗后内异症患者血清PP14和CA125水平也均呈现显著性下降(P均<0.05);但内异症患者的腹腔液中PP14和CA125水平与对照组比较,差异均无统计学意义(P均>0.05)。卵巢子宫内膜囊肿患者的异位病灶组织中PP14阳性表达率为84%,而患者在位子宫内膜组织及对照组子宫内膜组织中PP14阳性表达率分别为6%及5%,且均为弱阳性表达。结论 PP14可能参与内异症的发病机制。血清PP14可能作为内异症疗效监测的指标之一。Objective To approach primarily the role of placental protein 14 （PP14） in the pathogenesis of endometriosis by detection of the PPI4 levels in peritoneal fluid （PF） and serum, and PP14 expression in endometriotic lesions in women with endometriosis. Methods The levels of PPI4 and CA125 in PF and serum from 75 women with ovarian endometriosis and 49 women without endometriosis were determined with ELISA, and PP14 expression in endometriotic lesions were detected by immunohistochemical staining. Results The concentrations of PP14 and CA125 in serum were both significantly higher in women with endometriosis than those in women without endometriosis （ P 〈 0. 05 ）. After GnRHa therapy, the concentrations of PP14 and CA125 in serum were also significantly decreased in women with endometriosis （P 〈0.05）. However, the concentrations of PP14 or CA125 in PF did not show significant difference hetween women with and without endometriosis （P 〉 0. 05）. PP14 expression could be detected, respectively, in 84% of ovarian endometriotic lesions, in 6% of eutopic endometrial tissues of women with endometriosis, and in 5% of control endometrial tissues. Conclusion PP14 may play a role in the pathogenesis of cndometriosis, and may also he used as a marker for monitoring the therapeutic effects of the disease.

关 键 词：子宫内膜异位症 胎盘蛋白14 癌抗原125 血清 腹腔液 

分 类 号：R711.71[医药卫生—妇产科学]