加味芪丹糖肾方治疗糖尿病肾病Ⅴ期的临床研究  

Clinical research on Jiawei-qidan-tangshen decoction in the treatment of patients with diabetic nephropathy in V Period

作　　者：宋怡萍[1] 曾娟花[1] 刘丽红[2] 

机构地区：[1]上海中医药大学附属龙华医院内分泌科,200032 [2]中国中医科学院中医药信息研究所科学数据研究室,北京100700

出　　处：《国际中医中药杂志》2013年第5期399-401,共3页International Journal of Traditional Chinese Medicine

摘　　要：目的通过用药前后血肌酐（Scr）、血尿素氮（BUN）、胱抑素C（CysC）的变化观察加味芪丹糖肾方对于糖尿病肾病（DN）V期患者的疗效。方法将60例DNV期患者按照随机数字表法随机分为治疗组（美卡素联合加味芪丹糖肾方）、对照组（美卡素）各30例，治疗前后分别检测糖化血红蛋白（HbAlc）、Scr、BUN、CysC。结果治疗12周后，治疗组Scr、CysC[分别为（119．19±37．06）gmol／L、（1．81±0．69）mg／L]均下降（P〈0．01），对照组[分别为（147．25±62．70）!amoFL、（2．04±1．20）mg／L]无明显变化（P〉0．05）。治疗组对于Scr、CysC的总有效率分别为73．33％、83．33％，对照组分别为40．00％、53．33％，两者比较差异均有统计学意义（P均〈0．05）。结论加味芪丹糖肾方对于DNV期患者疗效可靠，且无明显不良反应。Objective Through observing the changes of serum creatinine （Scr）, blood urea nitrogen （BUN）, and Cystatin C （Cys C） to prove whether the treatment of patients of diabetic nephropathy （DN） in V period with Jiawei-qidan-tangshen decoction is really effective. Methods 60 patients of DN in V period were randomly divided into a treatment group and a control group by random number table method, with 30 patients in each group. Glycated hemoglobin （HbAlc）, serum creatinine （Scr）, blood urea nitrogen （BUN）, and Cystatin C （Cys C） were detected before and after the treatment. Results 12 weeks after treatment, Scr, Cys C （19.19±37.06） μmol/L, （1.81 ±0.69） mg/L had significantly declined in the treatment group （P〈0.001）, and had no significant change （147.25 ±62.70）μmol/L, （2.04±1.20） mg/L in the control group （P〉 0.05）. Total effective rate of Scr and Cys C was 73.33% and 83.33% in the treatment group and 40% and 53.33% in the control group respectively, both showing significant difference （P〈0.05）. Conclusion It is effective to treat patients of DN in V period with ,Jiawei-qidan-tangshen decoction, and have no obvious side effects.

关 键 词：加味芪丹糖 肾方 糖尿病肾病V期 血肌酐 胱抑素C 

分 类 号：R259[医药卫生—中西医结合] R277.5[医药卫生—中医内科学]