低分子肝素钠预防过敏性紫癜肾炎机制研究  

The Mechanism of the Prevention of Renal Damages with Henoeh-Sehonlein Purpura by Low Molecular Weight Heparin Sodium (LMWH)

作　　者：张帆 张宝国 蒋海萍 唐荣 嵇志敏 

机构地区：[1]永州市中心医院北院肾内科,湖南永州425000

出　　处：《现代生物医学进展》2013年第7期1345-1348,1366,共5页Progress in Modern Biomedicine

摘　　要：目的:探讨低分子肝素钠预防患儿过敏性紫癜肾炎的临床机制。方法:将60例患儿随机分为治疗组(30例)和对照组(30例)。治疗组在常规治疗基础上给予低分子肝素钠。观察两组临床症状消失时间及尿常规异常情况。比较两组疗效、肾损害的情况及比较治疗前、治疗1个月、3个月后复查尿微量白蛋白(Alb)、β2-微球蛋白(β2-mG)含量的变化以及血清IL-8的水平。结果:治疗组临床症状消失时间,尿常规异常明显低于对照组。两组疗效比较,差异无统计学意义(P>0.05)。治疗组肾损害发生率低于对照组。治疗1个月后、3个月后治疗组尿Alb及β2-mG和血清IL-8水平均明显低于对照组(P<0.05)。结论:低分子肝素钠能预防或减少HSPN的发生,具有显著的肾脏保护作用,可能与其降低血清IL-8水平有关。Objective： To investigate the clinical prevention effect of low molecular weight heparin sodium （LMWH） on renal damages in children with Henoeb-Sehonlein purpura （HSP）. Methods： 60 paitents with HSP were divided randomly into treatment group （30 cases） and control group （30 cases）. The treatment group was given low molecular heparin sodium on the basis of conventional treat- ment. The clinical symptoms disappear time and abnormal conditions of routine urine were observed. The levels of micro atbuminuria （Alb）, [32-micro globulin （[32-mG） content changes in urine and serum intefleukin （IL）-8 were detected in the two groups before treatment, after 1 month, 3 months. Results： The clinical symptoms disappeared time, abnormal routine urine in the treatment group were significantly lower than the control group, in curative effect between the two groups （P〉0.05）. The treatment group renal damage rate and the urine Alb, β2-raG levels and the serum level of IL-8 in treatment group were significantly lower than those in control group after one month and 3 months （P〈0.05）. Conclusions： Low molecular heparin sodium can prevent or reduce the occurrence of HSPN, and it had the remarkable renal protection that wouldbe related to its reducing of the serum level of IL-8.

关 键 词：低分子肝素钠 过敏性紫癜肾炎 抗凝 白介素8 

分 类 号：R692.34[医药卫生—泌尿科学]