解偶联蛋白-866G/A基因多态性与肥胖关联性的Meta分析(英文)  

Meta-analysis on the Relationship between UCP2 -866G/A Gene Polymorphism and Obesity

作　　者：刘玲玲[1] 赵新新[1] 康闪[1] 胡平[1] 张东峰[1] 

机构地区：[1]青岛大学医学院,山东青岛266011

出　　处：《现代生物医学进展》2013年第8期1421-1425,共5页Progress in Modern Biomedicine

基　　金：Natural Science Foundation of Shandong Province(ZR2010HM100)~~

摘　　要：目的:近年来,关于UCP2-866G/A基因多态性与肥胖关系的研究较多,但各研究的结果不尽一致。本文拟采用Meta分析的方法,对已公开发表的有关UCP2-866G/A基因多态性与肥胖的研究进行系统综合定量分析,以期科学的评价UCP2-866G/A基因多态性与肥胖的关系。方法:本研究运用计算机检索万方全文数据库、中国知网、维普数据库、中国生物医学文献数据库、PubMed等数据库收集关于UCP2-866G/A基因多态性与肥胖相关的公开发表的文献,选择OR值及其95%CI作为Meta分析指标。利用Stata10.0软件对各研究结果进行异质性检验和效应值合并计算。结果:根据统一的纳入和剔除标准,纳入14篇文献,共有肥胖者5195例,对照组9735人。在总人群中,UCP2-866G/A位点A/G的OR=0.931(95%CI:0.884-0.980),AA+GA/GG的OR=0.924(95%CI:0.859-0.994),AA/GG的OR=0.886(95%CI:0.797-0.985),GA/GG的OR=0.925(95%CI:0.856-0.999),有统计学意义。在欧洲人群中,UCP2-866G/A位点A/G的OR=0.912(95%CI:0.857-0.970),AA+GA/GG的OR=0.882(95%CI:0.808-0.962),AA/GG的OR=0.846(95%CI:0.743-0.963),GA/GG的OR=0.893(95%CI:0.814-0.980),有统计学意义。但在亚洲人群中均无统计学意义。结论:我们认为-866G/A基因多态性与欧洲人群的肥胖有关,与亚洲人群的肥胖无关。Objective： To evaluate the associations between UCP2 -866G/A polymorphism and obesity. Methods： A computerized search on literature was carried out in Wanfang, CNKI, VIP databases, CBM and PubMed to collect articles that concerning the associations between UCP2-866G/A polymorphisms and obesity. Odds ratios （ORs） were used to assess the strength of the association, and 95 % confidence intervals （CIs） to present the precision of the estimates. Meta-analysis was performed using the STATA statistical software. Results： 14 studies including 5195 obese cases and 9735 controls were collected for this meta-analysis. The meta-analysis showed significant association of the A allele with reduced risk of obesity in overall and European analysis in all mentioned models except the recessive model, But not in Asian. Conclusion： It suggested that UCP2 -866G/A polymorphism might be associated with obesity in European people, but not in Asian people.

关 键 词：META分析 基因多态性 肥胖 解偶联蛋白2 -866G A 

分 类 号：Q75[生物学—分子生物学] Q78