依达拉奉预先给药对二氧化碳气腹致腹腔镜妇科手术患者心肌损伤的影响  

Effect of edaravone pretreatment on myocardial injury induced by carbon dioxide pneulnoperitoneum in patients undergoing laparoscopic gynecologic surgery

作　　者：付俊[1] 肖昀[1] 钟和英[1] 冉然[1] 顾俊峰[1] 余开锋[1] 

机构地区：[1]湖北医药学院附属人民医院麻醉科,湖北十堰442000

出　　处：《中国医师进修杂志》2013年第12期12-14,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 评价依达拉奉预先给药对二氧化碳气腹致腹腔镜妇科手术患者心肌损伤的影响.方法 选择择期腹腔镜下行妇科恶性肿瘤切除术患者30例,ASA分级Ⅰ或Ⅱ级,按随机数字表法分为对照组和依达拉奉组,每组15例.依达拉奉组气管插管后给予依达拉奉0.5 mg/kg,对照组给予等容量的0.9％氯化钠.维持二氧化碳气腹压力10～15 mm Hg（1 mm Hg=0.133 kPa）.于麻醉诱导前及术后8h采集静脉血测定血清肌酸激酶（CK）、肌酸激酶同工酶MB（CK-MB）、天冬氨酸氨基转移酶（AST）和乳酸脱氢酶（LDH）.结果 对照组术后8h血清CK和AST明显高于麻醉诱导前和同期依达拉奉组[（205±27） U/L比（123±25）、（123±29） U/L,（48±5）U/L比（34±3）、（36±5）U/L],差异均有统计学意义（P＜0.05）,两组间和组内血清CK-MB和LDH比较差异均无统计学意义（P＞0.05）.结论 预先静脉输注依达拉奉0.5 mg/kg对腹腔镜妇科手术患者心肌可产生保护作用.Objective To investigate the effect of edaravone pretreatment on myocardial injury induced by carbon dioxide pneumoperitoneum in patients undergoing laparoscopic gynecologic surgery.Methods Thirty patients undergoing laparoscopic gynecologic surgery,ASA Ⅰ or Ⅱ grade,were divided into two groups by random digits table with 15 cases each：control group and edaravone group.Edaravone group following tracheal intubation received vein infusion of edaravone 0.5 mg/kg,control group received equal volume of 0.9% sodium chloride.The carbon dioxide pneumoperitoneum pressure was maintained at 10-15 mm Hg （1 mm Hg =0.133 kPa）.Venous blood samples were collected before anesthesia induction and after operation 8 h for the measurement of the serum creatine kinase （CK）,creatine kinase-MB （CK-MB）,aspartate aminotransferase （AST） and lactate dehydrogenase （LDH）.Results The serum levels of CK and AST were significantly higher after operation 8 h in control group than those of before anesthesia induction in control group and after operation 8 h in edaravone group [（205 ± 27） U/L vs.（123 ± 25） and （123 ± 29）U/L,（48±5） U/L vs.（34 ±3） and （36 ±5） U/L,P〈0.05].There was no significant difference in the serum levels of CK-MB and LDH between two groups and the group （P 〉 0.05）.Conclusion Pretreatment with edaravone 0.5 mg/kg can protect myocardium in patients undergoing laparoscopic gynecologic surgery.

关 键 词：依达拉奉 腹腔镜检查 气腹 人工 心肌 

分 类 号：R713[医药卫生—妇产科学]