D-二聚体、纤维蛋白原联合检测在肺栓塞诊断中的应用价值  被引量:8

Study on value of combined detection of D-D,Fg in pulmonary embolism

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作  者:王华启[1] 李萍[1] 陈腾飞[1] 张国俊[1] 

机构地区:[1]郑州大学第一附属医院呼吸内科,郑州450052

出  处:《医药论坛杂志》2013年第3期9-10,共2页Journal of Medical Forum

摘  要:目的探讨血浆D-二聚体(D-D)、纤维蛋白原(Fg)联合检测在肺栓塞早期诊断中的应用价值。方法用STAGOSTA Compact全自动血凝仪分别检测肺栓塞(PE)患者和正常健康人中的D-二聚体和纤维蛋白原(Fg)的水平。结果肺栓塞患者血浆D-二聚体和Fg水平均高于正常组。D-二聚体和Fg单独检测PE的灵敏度分别为91.7%、70.8%,特异度为85.4%、52.1%,两者联合检测PE的灵敏度为97.9%、特异度为60.4%。结论联合检测血浆中D-二聚体和Fg能够用于早期诊断肺栓塞,并可作为排除肺栓塞的筛选检查。Objective To evaluate the value of combined analysis of D-D, Fg in pulmonary embolism (PE). Methods Plasma level of D-D and Fg in each patient was determined with STAGOSTA Compact, plasma levels of D-D and Fg were collected from 48 cases with PE,48 cases healthy volunteers. Results The concentration of D^D and Fg in PE group were higher than those in helthy volunteers group (P 〈 0. 05). The sensitivity rates of D-D and Fg in PE were 91.7%, 70. 8%, respectively, the specific rates were 85.4% ,52. 1%, respectively. In combined assay of D-D and Fg, the sensi- tivity rate was 97. 9% , the specificity rate was 60. 4% comparing with the single assay, combined analysis had much high- er diagnostic sensitivity. Conclusions The assay of D-D and Fg is significant in diagnosis of PE. which can improve the rate of early PE.

关 键 词:D-二聚体 纤维蛋白原 肺栓塞 

分 类 号:R563.5[医药卫生—呼吸系统]

 

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