血浆瘦素及5-羟色胺与早泄的关系  

Association among leptin, 5-HT and premature ejaculation

作　　者：周勇[1] 汤坤龙[1] 王宝龙[1] 杨琳[1] 李黎明[1] 杨长海[1] 

机构地区：[1]天津医科大学总医院泌尿外科,300052

出　　处：《中华内分泌外科杂志》2013年第2期160-164,共5页Chinese Journal of Endocrine Surgery

基　　金：天津医科大学科学基金（2011KY02）

摘　　要：目的探讨血浆瘦素（1eptin）与5羟色胺（5-HT）之间的关系及2者在早泄诊断中的意义。方法招募71例终身性早泄患者为试验组及64例正常男性为对照组。予试验组为期8周盐酸舍曲林治疗，对照组不予治疗。测定受试者治疗前后血浆leptin及5-HT水平，并通过射精潜伏期、中国早泄患者性功能评分表对射精功能进行评估。结果治疗前试验组血浆leptin水平明显高于对照组，而5-HT水平低于对照组。8周后试验组血浆leptin水平下降，与正常对照组比较，差异无统计学意义（P〉0．05），而血浆5-HT水平大幅上升并趋于对照组水平。对于早泄，瘦素的敏感性和特异性分别为87．5％和96．3％，5-羟色胺的敏感性和特异性为92．2％和93．0％。结论血浆高水平leptin与低水平5-HT是早泄患者的生物学指标，这2者的测定对诊断早泄具有重要指导意义。Objective To investigate the interrelationship between leptin and 5-hydroxy tryptamine （5- HT） and their significance in diagnosis of premature ejaculation（PE）. Methods 71 cases with lifelong PE（ the trial group）and 64 healthy males（ the control group）were enrolled in this case-control study. Baseline recording of intravaginal ejaculation latency time（IELT） using a stop watch and Chinese Index of Premature Ejaculation-5 （CI- PE-5 ）were done. The serum leptin and 5-HT levels were determined. Then the trial group were given sertraline hydrochloride for 8 weeks, while the control group were not given any medicine treatment in this period. Reas- sessment was done after 8 weeks. Results At the baseline, the leptin level in the trial group was obviously high- er than the control group（ P 〈 0. 05 ）, while 5-HT level in the trial group was far lower than the control group（ P 〈 0. 05 ）. After 8 weeks, the leptin level of the trial group dropped and the difference had no statistical significance with that of the control group（P 〉0. 05）. 5-HT level of the trial group rose to the level very close to that of the control group after the treatment. Conclusion The high level of serum leptin and low level of serum 5-HT were the meaningful biological indicators for PE, which can potentially be applied in PE diagnosis.

关 键 词：早泄 射精潜伏期 瘦素 5-羟色胺 

分 类 号：R698[医药卫生—泌尿科学]