Fischer法合成2,5-二甲基吲哚的工艺研究  

Study on Synthesis of 2,5-Dimethylindole by Fischer Method

作　　者：徐小军[1] 尤庆亮[1,2] 余朋高[1] 喻宗沅[1] 

机构地区：[1]湖北省化学研究院,湖北武汉430074 [2]江汉大学,湖北武汉430056

出　　处：《化学与生物工程》2013年第4期59-62,共4页Chemistry & Bioengineering

摘　　要：采用Fischer法,以4-甲基苯肼盐酸盐为原料,经碱中和后与丙酮反应生成4-甲基丙酮苯腙,再在ZnCl2催化下进行成环反应,合成了2,5-二甲基吲哚,收率为64.4%,经乙醇与水重结晶后纯度达99.5%。产物结构经1 HNMR、13 CNMR、MS、IR表征确认。该工艺反应步骤少、原料价廉易得,适合规模化制备。In this essay,2,5-dimethylindole was successfully synthesized by Fischer method from 4-methyl- phenylhydrazine hydrochloride through its reaction with acetone after neutralization reaction to afford 4-methyl acetone phenylhydrazone and the following cyclization reaction catalyzed by zinc chloride. The purity and yield of 2,5-dimethylindole was 99. 5% and 64.4%, respectively after recrystallization by ethanol and water. The structure of the final product was characterized by 1 HNMR, 13CNMR, MS, IR. The synthetic process has advan- tages of taking brief reaction steps, using cheap and common materials and being suitable for scale preparation.

关 键 词：Fischer法 2 5-二甲基吲哚 合成 

分 类 号：TQ251.34[化学工程—有机化工] O626.13[理学—有机化学]