D二聚体、CRP及脂联素在慢性阻塞性肺疾病的临床意义  

The clinical significance of D-dimer,CRP and adiponectin in patients with chronic obstructive pulmonary disease

作　　者：张慧斐[1] 王冬莲 阮奕[1] 何小帆[1] 

机构地区：[1]台州医院,浙江临海317000

出　　处：《中国卫生检验杂志》2013年第4期914-916,918,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨D二聚体、CRP及脂联素在慢性阻塞性肺疾病的临床意义。方法:收集2009年7月-2011年12月期间在我院住院的慢性阻塞性肺疾病男性患者共268例以及同期来我院的健康男性体检者,采用免疫比浊法测定血浆D二聚体水平,采用ELISA法测定血清脂联素水平,采用免疫散射速率比浊法测定C反应蛋白(CRP);同时测定慢阻肺病人的氧分压、二氧化碳分压以及肺功能。结果:COPD急性加重期D二聚体、脂联素和CRP均比稳定期和健康体检者显著增加,COPD稳定期脂联素较健康体检者增加。运用Spearman相关分析,FEV1/FVC与脂联素,CRP,D二聚体均呈负相关。COPD4期的脂联素与CRP较2期和3期增高(P<0.05)。结论:脂联素可能和COPD严重程度有关系,对COPD患者,联合检测D二聚体、CRP和脂联素,早期治疗,有助于改善患者预后。Objective：To explore the clinical significance of the D-dimer,CRP and adiponectin in patients with chronic obstructive pulmonary disease.Methods： A total of 268 male patients with chronic obstructive pulmonary disease and the healthy male volunteers were included from July 2009 to December 2011.The plasma D-dimer level were detected by immune turbidimetric method;serum adiponectin level were detected by ELISA;C-reactive protein（CRP） were detected by immune scattering rate turbidimetric method.And the partial pressure of oxygen,carbon dioxide partial pressure and pulmonary function of patients with COPD were determined too.Results： The D-dimer,CRP and adiponectin in patients with acute exacerbation COPD were higher than those with stable and healthy subjects.The serum adiponectin level was higher in stable COPD than that in healthy male volunteers.Adiponectin,CRP and D-dimer were negatively correlated with FEV1/FVC in the COPD patients.The level of the serum Adiponectin and CRP in the stage 4 COPD were higher than those in the stage 2 and stage 3 COPD（P0.05）.Conclusion： The adiponectin level might be associated with the severity of COPD.The detection of D-dimer,CRP and adiponectin,as well as early treatment are helpful for chronic obstructive pulmonary disease patients.

关 键 词：慢性阻塞性肺疾病 D二聚体 C反应蛋白 脂联素 

分 类 号：R563.5[医药卫生—呼吸系统]