N-(2-乙酰苯基)-2,5-二甲基吡咯的合成及其在卷烟加香中的应用研究  

Study on Synthesis of 1-(2-Acetylphenyl)-2,5-Dimethyl-1H-Pyrrole and Its Application in Tobacco Flavoring

作　　者：刘会杰[1] 姬小明[1] 赵铭钦[1] 张钺[1] 魏鹏程[1] 包晓蓉[1] 祁令凯[1] 

机构地区：[1]河南农业大学烟草学院,河南郑州450002

出　　处：《香料香精化妆品》2013年第2期12-16,共5页Flavour Fragrance Cosmetics

摘　　要：以邻氨基苯乙酮和2,5-己二酮为原料,通过Paal-Knorr反应合成了一种新型的N-取代吡咯衍生物N-(2-乙酰苯基)-2,5-二甲基吡咯。通过IR、1HNMR、13CNMR、HRMS等波谱方法对产物结构进行了确证,并研究N-(2-乙酰苯基)-2,5-二甲基吡咯的热稳定性以及在300℃、600℃和900℃的热裂解行为。结果表明,温度对合成物质的热裂解产物种类和含量有较大影响,裂解产物主要包括邻氨基苯乙酮、吡啶衍生物、醇等,其中含有多种致香物质,能够有效改善卷烟吸味,增强烟香。A new pyrrole ketone 1-（2-acetylphenyl）-2,5-dimethyl-1 H-pyrrole was synthesized using ortho aminoacetophenone and 2,5 hexanedione as raw materials via Paal-Knorr reaction. The structure of the product was confirmed by IR, ^1H NMR, ^13C NMR, HRMS spectral analysis. The thermal stability and cracking behavior of this pyrrole ketone were respectively studied at 300℃,600℃ and 900℃. The results showed that the temperature had great impact on type and content of pyrolysis products, which mainly included o-amino-acetophenone, pyridine derivatives, alcohols, etc. , they can improve and enhance the smoke of cigarette.

关 键 词：N-(2-乙酰苯基)-2 5-二甲基吡咯 合成 热裂解 

分 类 号：TQ655[化学工程—精细化工]