妊娠胆汁淤积症的胎心基线与甘胆酸含量的相关性及护理  

Analysis of the Associativity of Embryocardia Baseline with the Content of Glycocholic Acid in Patients with Intrahepatic Cholestasis of Pregnancy and the Nursing

作　　者：梁纯丽[1] 张再青[1] 郭子平[1] 邱海燕[1] 

机构地区：[1]深圳市第二人民医院产科,广东深圳518035

出　　处：《深圳中西医结合杂志》2013年第2期120-123,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨妊娠期肝内胆汁淤积症(ICP)患者的电子胎心监护基线变异与血清甘胆酸(CG)含量的相关性研究及护理对策。方法:采集被观察对象晨间空腹静脉血3mL,用放射免疫法(CGRIA)监测ICP孕妇血清的CG含量,选择同期55例无其它任何并发症的正常孕妇加以对照,同时进行电子胎心监护,监测其基线变异值的变化。结果:ICP患者组的CG100%高于正常妊娠组,其胎心电子监护中基线变异值低于正常妊娠组,差异均有统计学意义(P<0.01);正常妊娠组孕妇血清CG含量与电子胎心监护中基线变异值呈负相关(γ=0.52,P<0.05);ICP组孕妇CG含量与其电子胎心监护中基线变异值呈负相关(γ=0.52,P<0.05);电子胎心监护中基线变异的异常率在ICP患者组明显高于正常妊娠组(X2=4.377,P<0.05),差异有统计学意义。结论:ICP患者CG含量增高与其胎心电子监护中基线变异值呈负相关。临床可依据基线变异值有效地监测ICP患者妊娠的安全性,及时提供其治疗方案和护理对策。Objective To study the correlation of the content of glycocholic acid（CG） and the electronic embryocardia monitoring baseline variability of patients with intrahepatic cholestasis of pregnancy（ICP）, and to find the nursing countermeasure. Methods 3 mL fasting venous blood of subjects was drawn in morning. The serum content of CG in ICP pregnant woman was detected by using CG Radioimmunoassay （CG R/A）. 55 normal pregnant women without any pregnancy complications were selected as the control group. The fetal heart rate and the embryocardia baseline variability were detected by electronic monitor. Results The serum contents of glycocholic acid（CG） of intrahepatic cholestasis of pregnancy （ICP） patients were 100% higher than that of the normal group. The numerical values of the electronic fetal heart rate monitoring baseline variability in ICP group were all lower than those in the normal group, and the differences were statistically significant （P〈 0.01） The serum CG content of normal pregnancy group was significantly negatively correlated with the electronic fetal heart rate monitoring baseline variability （γ =0.52, P〈0.05）. The serum CG content of ICP group was significartly negatively correlated with electronic fetal heart rate monitoring baseline variability （γ =0.52, P 〈 0.05）. The abnormality rates of electronic fetal heartrate monitoring baseline variability in ICP patients were obviously higher than those in normal pregnancy group （χ2= 4.377, P〈 0.05）, the difference was statistically significant. Conclusion In ICP patients, the increase of serum CG corent is significantly negatively correlated with the value of electronic fetal heart rate monitoring baseline variability. In clinical, effective monitor of pregnancy safety for patients with ICP can be based on the baseline variation value, so as to promptly provide the timely treatment and nursing countermeasures.

关 键 词：妊娠期肝内胆汁淤积症 血清甘胆酸 胎心监护 基线变异 护理 

分 类 号：R714.25[医药卫生—妇产科学]