白花油质量标准研究  

Study on Quality Control of White Flower Embrocation

作　　者：胡世强[1] 张伟[1] 张永耀[1] 

机构地区：[1]广州市药品检验所,广州510160

出　　处：《中国药品标准》2013年第2期113-116,共4页Drug Standards of China

摘　　要：目的:提高白花油的质量控制标准。方法:用气相色谱-质谱法,DB-5MS毛细管柱(30m×0.25 mm,0.25μm),程序升温,进样口温度为250℃,载气为高纯氦气,流量为1mL.min-1,分流比为100∶1,离子源温度为200℃,接口温度为300℃,电离方式为EI。结果:芳樟醇在0.513～10.27 ng范围内、樟脑在1.23～24.60 ng范围内、薄荷脑在5.089～101.18 ng范围内、水杨酸甲酯在7.032～140.64 ng范围内均呈现良好的线性关系,芳樟醇的回收率为105.3%,RSD为2.0%;樟脑的回收率为103.5%,RSD为2.1%;薄荷脑的回收率为104.0%,RSD为1.5%;水杨酸甲酯的回收率为99.5%,RSD为1.5%。结论:采用气相色谱-质谱法可对白花油中有效成分进行定性和定量分析,方法简便、准确,重现性好。Objective： To improve the standard of the quality control of White Flower Embrocation. Method： GC-MS device was a- dopted, on the DB-5 chromatographic column（30 m × 0. 25 mm × 0. 25 μm） with temperature programming, high-purity helium was as cartier gas and the injector temperature was set at 200 ℃. The split ratio was 100 ： 1, and the ion source temperature was at 200 ℃, the interface temperature was at 300 ℃. The Ionization mode was EI. Results： The linalool, camphor, menthol crystal, methyl salicy- late showed excellent linearity, which were respectively at the range of 0. 513-10. 27 ng, 1.23-24. 60 ng, 5.089-101.18 ng and 7. 032- 140. 64 ng. The average recoveries were 105.3% （RSD =2. 0% ）, 103.5% （RSD =2. 1% ）, 104. 0% （RSD = 1.5% ） and 99. 5% （RSD = 1.5% ）respectively. Conchlsion： The method was simple, sensitive and with good reproducibility. It can be used for the de- termination of linalool, camphor, menthol crystal and methyl salieylate in White Flower Embrocation.

关 键 词：气相色谱-质谱法 白花油 芳樟醇 樟脑 薄荷脑 水杨酸甲酯 

分 类 号：R921.2[医药卫生—药学]