明日叶查尔酮对2型糖尿病大鼠红细胞胰岛素受体亲和力的影响  

The Influence of Ashitaba Chalcone on the Affinity of Insulin Receptor in Erythrocytes of Rats with Type 2 Diabetes Mellitus

作　　者：曹卿[1] 王庆平[1] 钟进义[1] 张照杰[1] 王先红[1] 

机构地区：[1]青岛大学医学院,青岛山东266021

出　　处：《现代生物医学进展》2013年第11期2034-2036,2095,共4页Progress in Modern Biomedicine

摘　　要：目的:研究明日叶查尔酮对2型糖尿病大鼠红细胞胰岛素受体亲和力的影响。方法:将高脂喂养加链脲佐菌素注射诱发的2型糖尿病大鼠随机分为4组,每组10只。糖尿病对照组和高、中、低剂量组喂饲高脂饲料分别经口灌胃明日叶查尔酮0、30、10、5mg(kg.bw)-1,正常对照组为正常大鼠喂饲普通饲料,连续4周。测定空腹血糖、血清胰岛素与MDA、红细胞胰岛素受体结合常数与结合容量等指标。结果:高剂量组的高亲和力与低亲和力胰岛素受体结合常数高于糖尿病对照组,血糖、胰岛素和MDA含量则降低,差异均有显著性(P<0.05)。结论:明日叶查尔酮能提高2型糖尿病大鼠红细胞胰岛素受体亲和力,改善胰岛素抵抗。Objective： To observe the influence of ashitaba chalcone on the affinity of insulin receptor in erythrocytes of rats with type 2 diabetes mellitus. Methods： Rats with type 2 diabetes mellitus were induced with high fat diet and intraperitoneal injection with small dose of streptozotocin, then they were divided into 4 groups, 10 mice per group. Diabetes mellitus control group and high, medium, low ashitaba chalcone supplementation groups were induced with high fat diet, the dosage of ashitaba chalcone fed through mouth were 0, 30, 10, 5 mg （kg.bw）1. Normal control group were induced with normal diet. All rats were killed after four weeks. FPG, the srerum insulin level, MDA, the combination constants and combined capacity of erythrocytes insulin receptor were determined. Results： High affinity insulin receptor combination.constant and low affinity insulin receptor combination constant of high dosage group increased more than those of diabetes mellitus control group, Fasting plasma glucose, the serum insulin level and MDA were decreased, all have significant difference （P 〈 0.05）. Conclusion： Ashitaba chalcone could improve insulin receptor in erythrocytes affinity of type 2 diabetic rats, and improve insulin resistance.

关 键 词：明日叶查尔酮 糖尿病 胰岛素受体 血糖 

分 类 号：Q95-3[生物学—动物学] R587.1[医药卫生—内分泌]