脂肪负荷餐中脂肪酸构成比的探讨  

Study of Fatty Acids Composition Ratio of Oral Fat Loads Used in Postprandial Lipids and Lipoproteins Metabolism

作　　者：戴军[1] 苏宜香[1] 凌文华[1] 梁亦铨[2] 钟春宁[3] 欧香忠[2] 

机构地区：[1]中山医科大学公共卫生学院医学营养系 [2]中山医科大学附属第一医院内分泌科 [3]中山医科大学分子医学中心,广州510089

出　　处：《中国动脉硬化杂志》2000年第3期251-255,共5页Chinese Journal of Arteriosclerosis

基　　金：中山医科大学科研基金!(5 2 2 30 1118)资助

摘　　要：拟探讨不同脂肪酸构成比脂肪负荷餐对Ⅱ型糖尿病患者餐后血脂代谢的影响 ,为同类研究奠定方法学基础。将 2 8例糖尿病患者按分层抽样被分为 3组 ,禁食 12h ,分别接受 1∶1∶1、1∶1.7∶1.2和 1∶1.7∶2 .3三种不同脂肪酸构成比脂肪负荷餐。测定餐前及餐后 2、4、6h血浆甘油三酯、总胆固醇、高密度脂蛋白胆固醇、载脂蛋白A1和载脂蛋白B的浓度 ,低密度脂蛋白胆固醇浓度计算得出。结果发现各组餐后各时间点甘油三酯较餐前明显升高 ,1∶1∶1、1∶1.7∶1.2和 1∶1.7∶2 .3组甘油三酯达峰时间分别为 2～ 4、4和 4～ 6h ;各组餐后 4h低密度脂蛋白胆固醇明显低于餐前。 1∶1.7∶1.2组餐后 2h血浆甘油三酯增值明显高于 1∶1.7∶2 .3组 ,1∶1.7∶2 .3组低密度脂蛋白胆固醇餐后 6h浓度和曲线下面积明显低于 1∶1∶1和 1∶1.7∶1.2组。表明脂肪酸构成比可从血脂浓度、达峰时间、餐后脂质总水平三方面影响脂肪负荷餐后Ⅱ型糖尿病患者代谢动态 ,建议脂肪负荷餐采用 1∶1.7∶1.2脂肪酸构成比。Aim To explore the effects of different ratios of saturated, monounsaturated and polyunsaturated fatty acids of oral fatty loads on the postprandial lipids and lipoproteins metabolism. Methods The oral fatty loaded tests with three different fatty acids ratio. Results (1) Lipid concentrations: Triglyceride responded greatly to the oral fatty loads in three groups. The triglyceride in 2, 4, 6 hour plasma after the loads was significantly higher than fasting triglyceride, respectively (P<0.05). No significant total cholesterol changes occurred but high density lipoprotein cholesterol and low density lipoprotein cholesterol significantly decreased in group Ⅱ and Ⅲ. The increment of triglyceride at 2 hour after the test meal was significantly higher in group Ⅱ than group Ⅲ (P<0.05). Low density lipoprotein cholesterol in 6 hour plasma in group Ⅲ was significantly lower than that in group Ⅱ and Ⅲ (P<0.05). (2)Peak time:Triglyceride in group Ⅰ, Ⅱ and Ⅲ peaked at 2～4, 4 and 6 hours after the fatty load. High density lipoprotein cholesterol and apoprotein A1 in group Ⅱ and Ⅰ were lowest at 4 hours after the loads but at 6 h in group Ⅲ. (3)Area under the curve: Area under the curve of low density lipoprotein cholesterol in group Ⅲ was markedly smaller than in group Ⅱ. Conclusion The study showed that fatty acids composition ratios of oral fatty loads influenced the dynamic metabolism of the postprandial lipids and lipoproteins metabolism in type Ⅱ diabetic patients. We suggested that the fatty acid composition ratio of 1∶1.7∶1.2 could be used in the fatty load.

关 键 词：脂肪酸 高脂血症 脂蛋白 载脂蛋白 糖尿病 

分 类 号：R587.202[医药卫生—内分泌] R459.3[医药卫生—内科学]