肝动脉化疗栓塞及注射^(32)P-胶体、无水乙醇综合序贯介入治疗原发性肝癌疗效分析  

Therapeutic effect of combination and sequential intervention treatment on primary liver cancer with TACE,radioactive colloidal phosphate and PEI

作　　者：张长清[1] 李彦豪[2] 吴伟岗[1] 曾志雄[1] 徐明符[3] 高秀荣[3] 张万福[3] 

机构地区：[1]福建省泉州市第一医院消化科,泉州362000 [2]广州第一军医大学南方医院放射科 [3]广州市第一军医大学珠江医院消化科

出　　处：《胃肠病学和肝病学杂志》2000年第3期225-226,共2页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的评价肝动脉化疗栓塞及Ｂ超引导下注射３２Ｐ－胶体、无水乙醇（ＰＥＩ）综合序贯介入治疗原发性肝癌的临床价值。方法 ５１例中晚期肝癌分为 ２组， ２３例综合序贯应用 ＴＡＣＥ＋３２Ｐ＋ ＰＥＩ治疗， ２８例单纯应用 ＴＡＣＥ治疗。结果综合序贯组肿瘤缩小率、肿瘤完全坏死率、ＡＦＰ下降率分别为９１．２９％、８０．００％、８７．５％，而单纯ＴＡＣＥ组分别为３９．２７％、３０．４３％、４１．４６％，两组比较有显著性差异（Ｐ＜０．０１）。０．５、１、２、３年生存率综合序贯组分别为９５．６５％．８６．９５％、５６．５２％、２０．７３％，而单纯ＴＡＣＥ组分别为６４．２８％、３９．２８％、１７．８５％、００．００％（Ｐ＜０．０１）。结论ＴＡＣＥ＋３２Ｐ＋ＰＥＩ的综合序贯介入治疗是提高中晚期原发性肝癌患者生存率的有效方法。Aim To evaluate the clinical efficacy of transcatheter arterial chemoembolization (TACE ) combined with radioactive colloidal phosphate (32P) and percutaneous ethanol injection (PEI) in the treatment of primary liver cancer (PLC). Method 51 cases of moderate and advanced stages of PLC were divided into two groups, 23 cases were treated with TACE and followed subsequently by 32 P and PEI(group A),28 cases were heated with TACE alone(group B). Results the rate of reduction in tumor diameter and tumor complete necrosis and the decline in serum AFP level in group A were 91. 29%, 90.(X)% and 87 .5%,while those in group B were 39.27%,30.43% and 41 .46% respectively.There was significant difference between the two groups(P < 0.01). The 0.5, 1,2,3 year survival rates of group A were 95. 65%,86.95%,56.52% and 20.73%, respectively, in contrast, those of group B were 64. 28%, 39. 28%, 17. 85% and 00. 00%, respectively(P < 0. 01 ). Conclusion The combination and sequential intervention treatment on PLC with TACE, radioactive colloidal phosphate (32p) and PEI was an efficient method of increasing the survival rate.

关 键 词：肝动脉 化疗栓塞 胶体^32P 无水乙醇 原发性肝癌 

分 类 号：R735.705[医药卫生—肿瘤]