血脂清颗粒在高血压合并代谢综合征治疗中的减毒增效作用  

Attenuated and Synergistic Effect of Blood Fat Clear Particles in Hypertension Patients with Metabolic Syndrome

作　　者：刘德桓[1] 陈文鑫 王秀宝[1] 叶靖[1] 欧凌君[1] 苏齐 吴志阳[1] 

机构地区：[1]福建中医药大学附属泉州市中医院,福建泉州362000 [2]泉州市医药研究所,福建泉州362000

出　　处：《中国中医药信息杂志》2013年第5期9-12,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：泉州市科技局重点项目(2009Z40)

摘　　要：目的观察血脂清颗粒在高血压病合并代谢综合征(MS)治疗中的减毒增效作用。方法将90例患者随机分为3组,每组30例,阿托伐他汀钙片组给予阿托伐他汀钙片,血脂清组给予阿托伐他汀钙片颗粒,联合治疗组给予立普妥加血脂清颗粒治疗。疗程8周,观察治疗前后血压、血糖、血脂的变化以及安全性。结果治疗后,3组的血压水平变化无统计学意义(P>0.05)。血脂清颗粒和阿托伐他汀钙片均可以有效降低三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及升高高密度脂蛋白胆固醇(HDL-C),且降低LDL-C效果二者比较差异无统计学意义。联合治疗组与阿托伐他汀钙片组降低TC效果比较,差异无统计学意义。联合治疗组餐后2 h血糖、糖化血红蛋白、血尿酸水平均明显下降(P≤0.001);与其他2组比较,差异有统计学意义(P≤0.01)。血脂清组与联合治疗组的肝、肾功能及肌酸激酶治疗前后比较,差异无统计学意义(P>0.05)。结论血脂清颗粒与阿托伐他汀钙片联合用药后,其减毒增效作用显著,是治疗高血压合并MS的一种较好选择。Objective To observe the attenuated and synergistic effect of Blood fat clear particles in hypertension patients complicated with metabolic syndrome.Methods Ninety patients were randomly divided into three groups,30 cases in each group.Atorvastatin group was given atorvastatin,Blood fat clear group was given Blood fat clear particles,and combined treatment group was given Lipitor and Blood fat clear particles for 8 weeks.The change of blood pressure,blood glucose,blood lipid parameters and safety before and after treatment were observed.Results After treatment,the change of blood pressure level had no statistical difference in 3 groups（P 0.05）.Blood fat clear particles effectively reduced TG,TC, LDL-C and increased HDL-C,its effect of reducing LDL-C had no significant difference with atorvastatin. There was no significant difference in dropping TC between combined treatment group and atorvastatin group.The levels of 2 h PG,HbA1c and UA declined obviously in combined treatment group after treatment（P ≤0.001）,and had significant difference with that in atorvastatin group and Blood fat clear group（P ≤0.01）.The liver and kidney function and creatine kinase had no significant difference（P 0.05） between before and after treatment in both Blood fat clear group and combined treatment group. Conclusion Blood fat clear combined with atorvastatin is the better choice in treating hypertension complicated with metabolic syndrome,which has attenuated and synergistic effect.

关 键 词：高血压病 代谢综合征 血脂清颗粒 阿托伐他汀钙片 减毒增效 

分 类 号：R259.441[医药卫生—中西医结合] R259.89[医药卫生—中医内科学]